ArticleJournal of toxicology and environmental health. Part A2015
Kidney biomarkers associated with blood lead, mercury, and cadmium in premenopausal women: a prospective cohort study.
Article in Journal of toxicology and environmental health. Part A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Toxic Metals and Chronic Kidney Disease: a Systematic Review of Recent Literature.Current environmental health reports · 2018Pooled it
- Cadmium exposure and risk of pancreatic cancer: a meta-analysis of prospective cohort studies and case-control studies among individuals without occupational exposure history.Environmental science and pollution research international · 2015Pooled it
- Metal carcinogens and cancer: integrating genetic and epigenetic perspectives.Frontiers in oncology · 2026Review
- Associations of Blood and Urinary Heavy Metals with Stress Urinary Incontinence Risk Among Adults in NHANES, 2003-2018.Biological trace element research · 2025Article
- INFERRING SYNERGISTIC AND ANTAGONISTIC INTERACTIONS IN MIXTURES OF EXPOSURES.The annals of applied statistics · 2025Article
- The Effect of Selenium Against Cadmium-Induced Nephrotoxicity in Rats: The Role of the TRPM2 Channel.Toxics · 2025Article
- Article
- The Protective Activity ofInternational journal of nephrology · 2024Article
- Coral fossil: A potential adsorbent of natural source for cadmium removal in broilers.Saudi journal of biological sciences · 2023Article
- Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations.Biological trace element research · 2023Article
- Effects of Cadmium on Kidney Function of the Freshwater Turtles Mauremys reevesii.Biological trace element research · 2023Article
- Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia.International journal of environmental research and public health · 2023Article
- Non-essential and essential trace element mixtures and kidney function in early pregnancy - A cross-sectional analysis in project viva.Environmental research · 2023Article
- Association Between Blood Lead Level With High Blood Pressure in US (NHANES 1999-2018).Frontiers in public health · 2022Article
- Childhood lead exposure of Amerindian communities in French Guiana: an isotopic approach to tracing sources.Environmental geochemistry and health · 2021Article
- The Aging Kidney-As Influenced by Heavy Metal Exposure and Selenium Supplementation.Biomolecules · 2021Review
- Blood lead level monitoring related to environmental exposure in the general Iranian population: a systematic review and meta-analysis.Environmental science and pollution research international · 2021Review
- Soil Lead (Pb) in New Orleans: A Spatiotemporal and Racial Analysis.International journal of environmental research and public health · 2021Article
- Article
- Vitamin D and Reproductive Hormones Across the Menstrual Cycle.Human reproduction (Oxford, England) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Certain metals are harmful to the kidney and liver at high levels, but associations with functional biomarkers at low exposure levels among premenopausal women apparently has not been evaluated. Healthy, regularly menstruating women (n = 259) were followed for up to 2 menstrual cycles with up to 16 visits. Renal and liver biomarkers were measured in serum at each clinic visit. Cadmium (Cd), lead (Pb), and mercury (Hg) were measured in whole blood at baseline. Linear mixed models were adjusted for age, body mass index (BMI), race, average calories, alcohol intake, smoking, and cycle day. Median levels of Cd, Pb, and Hg were 0.31 μg/L, 0.88 μg/dl, and 1.1 μg/L, respectively. One-third of women had diminished glomerular filtration rate (eGFR) (<90 ml/min/1.73 m(2)). Each twofold increase in Cd was associated with a negative 4.9% change in blood urea nitrogen (BUN) and bilirubin. Each twofold rise in Pb was associated with decreased eGFR and increased creatinine. A twofold elevation in Hg was associated with higher protein and reduced alkaline phosphatase. In healthy, predominantly nonsmoking women, low levels of Cd, Pb, and Hg were associated with changes in select biomarkers of kidney and liver function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.