ArticleMacromolecular rapid communications2015
Temperature-triggered phase separation of a hydrophilic resilin-like polypeptide.
Article in Macromolecular rapid communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Engineering Design of Artificial Phase-Separating Proteins.Biotechnology journal · 2026Review
- Molecular Engineering of Recombinant Protein Hydrogels: Programmable Design and Biomedical Applications.Gels (Basel, Switzerland) · 2025Review
- A Novel Gene Synthesis Platform for Designing Functional Protein Polymers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Modeling biomolecular condensates across scales: Atomistic, coarse-grained, and data-driven approaches.Advances in physics: X · 2025Article
- Genetically Fused Resilin-like Polypeptide-Coiled Coil Bundlemer Conjugates Exhibit Tunable Multistimuli-Responsiveness and Undergo Nanofibrillar Assembly.Biomacromolecules · 2024Article
- Inducing an LCST in hydrophilic polysaccharides via engineered macromolecular hydrophobicity.Scientific reports · 2023Article
- Modulation of assembly of TDP-43 low-complexity domain by heparin: From droplets to amyloid fibrils.Biophysical journal · 2022Article
- Protein-Based Encapsulation Strategies: Toward Micro- and Nanoscale Carriers with Increased Functionality.Small science · 2022Article
- Protein Based Biomaterials for Therapeutic and Diagnostic Applications.Progress in biomedical engineering (Bristol, England) · 2022Article
- Microphase Separation of Resilin-like and Elastin-like Diblock Copolypeptides in Concentrated Solutions.Biomacromolecules · 2021Article
- Application of Thermoresponsive Intrinsically Disordered Protein Polymers in Nanostructured and Microstructured Materials.Macromolecular bioscience · 2021Review
- Resilin-mimetics as a smart biomaterial platform for biomedical applications.Nature communications · 2021Review
- De novo engineering of intracellular condensates using artificial disordered proteins.Nature chemistry · 2020Article
- Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties.Biomaterials science · 2020Article
- Recent trends in protein and peptide-based biomaterials for advanced drug delivery.Advanced drug delivery reviews · 2020Review
- Incorporation of short, charged peptide tags affects the temperature responsiveness of positively-charged elastin-like polypeptides.Journal of materials chemistry. B · 2019Article
- Temperature-Controlled Liquid-Liquid Phase Separation of Disordered Proteins.ACS central science · 2019Article
- Methods for producing microstructured hydrogels for targeted applications in biology.Acta biomaterialia · 2019Review
- Biocompatibility of injectable resilin-based hydrogels.Journal of biomedical materials research. Part A · 2018Article
- Designing Smart Materials with Recombinant Proteins.Macromolecular bioscience · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Temperature-triggered phase separation of recombinant proteins has offered substantial opportunities in the design of nanoparticles for a variety of applications. Herein, the temperature-triggered phase separation behavior of a recombinant hydrophilic resilin-like polypeptide (RLP) is described. The transition temperature and sizes of RLP-based nanoparticles can be modulated based on variations in polypeptide concentration, salt identity, ionic strength, pH, and denaturing agents, as indicated via UV-Vis spectroscopy and dynamic light scattering (DLS). The irreversible particle formation is coupled with secondary conformational changes from a random coil conformation to a more ordered β-sheet structure. These RLP-based nanoparticles could find potential use as mechanically-responsive components in drug delivery, nanospring, nanotransducer, and biosensor applications.
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Registered trials
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