Evidence map›Paper›PMID 25424602›Full record

Trial reportEuropean journal of clinical nutrition2015

Effect of a low-fat diet enriched either with rapeseed oil or sunflower oil on plasma lipoproteins in children and adolescents with familial hypercholesterolaemia. Results of a pilot study.

L Negele, B Schneider, R Ristl, T M Stulnig, A Willfort-Ehringer, O Helk, K Widhalm

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  3. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

L NegeleDivision of Clinical Nutrition and Prevention, Department of Paediatrics and Adolescents Medicine, Vienna Medical University, Vienna, Austria.
B SchneiderDepartment of Medical Statistics, Vienna Medical University, Vienna, Austria.
R RistlDepartment of Medical Statistics, Vienna Medical University, Vienna, Austria.ORCID 0000000241639236
T M StulnigClinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Vienna Medical University, Vienna, Austria.
A Willfort-EhringerDepartment of Angiology, Vienna Medical University, Vienna, Austria.
O HelkAustrian Academic Institute for Clinical Nutrition, Alserstraße 14/4, Vienna, Austria.
K WidhalmDivision of Clinical Nutrition and Prevention, Department of Paediatrics and Adolescents Medicine, Vienna Medical University, Vienna, Austria.
Medical University of Vienna · ATInstitute for Social Anthropology · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThere is convincing evidence that unsaturated fatty acids exert favourable effects on plasma cholesterol levels. However, it is not clear which type of oil has the most pronounced effect, especially not in paediatric patients. The aim was to compare two low-fat diet regimes enriched with either monounsaturated fatty acids by rapeseed oil (RO) or polyunsaturated fatty acids by sunflower oil (SO) in children affected with familial hypercholesterolaemia (FH). SUBJECTS/

methodsTwenty-one children aged 6-18 years affected with FH were enrolled in this randomized and double-blind pilot trial. The subjects and their families were trained to adhere to a low-fat/low-cholesterol diet. All visible fats were to be replaced by either RO or SO (14-27 g/day) for 13 weeks. Dietary adherence was controlled by repeated 4-day dietary records; plasma lipids, lipoproteins and risk markers were assessed at baseline and post-intervention. Out of 21 subjects, 16 could be followed-up after 6 months.

resultsBoth fat-modified diets resulted in significant reduction in total cholesterol concentrations of 9.4% (RO P<0.005 vs SO P<0.05) and low-density lipoprotein (LDL) cholesterol concentrations of 12.7% (P<0.005) for RO and 11.3% (P<0.05) for SO. The reduction of the LDL/high-density lipoprotein (HDL) cholesterol ratio (RO 9% vs SO 3.5%) and high-sensitivity C-reactive protein (RO 16.8% vs SO 1.7%) were not statistically significant, respectively. In most participating families, a change in eating habits could be observed.

conclusionsA fat-modified diet enriched with RO seems to have very similar effects on cholesterol levels as with SO. However, our study suggests that RO has possibly more favourable effects concerning cardiovascular risk profile. Both diets appear to be feasible and were well accepted among our subjects. Although these results are promising, larger trials will be required to validate our findings.

Indexed as

Diet, Fat-RestrictedAdolescentBrassica rapaChildCholesterolCholesterol, HDLCholesterol, LDLC-Reactive ProteinDietary Fats, UnsaturatedDouble-Blind MethodFatty Acids, MonounsaturatedFeeding BehaviorFemaleHelianthusHumansHyperlipoproteinemia Type IICholesterolCholesterol, HDLCholesterol, LDLC-Reactive ProteinDietary Fats, UnsaturatedFatty Acids, MonounsaturatedPlant OilsRapeseed OilSunflower Oil

Identifiers

PMID25424602
OpenAlexW1985594813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.