Trial reportEuropean journal of clinical nutrition2015
The interactive effect of improvement of vitamin D status and VDR FokI variants on oxidative stress in type 2 diabetic subjects: a randomized controlled trial.
Trial report in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Vitamin D deficiency and its associated factors among patients with type 2 diabetes mellitus: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Changes in Bone Turnover, Inflammatory, Oxidative Stress, and Metabolic Markers in Women Consuming Iron plus Vitamin D Supplements: a Randomized Clinical Trial.Biological trace element research · 2021Trial
- Genetic Variations in VDR could Modulate the Efficacy of Vitamin D3 Supplementation on Inflammatory Markers and Total Antioxidant Capacity among Breast Cancer Women: A Randomized Double Blind Controlled Trial.Asian Pacific journal of cancer prevention : APJCP · 2019Trial
- Oxidative stress in critically ill ventilated adults: effects of vitamin DEuropean journal of clinical nutrition · 2018Trial
- Vitamin D deficiency is associated with an oxidized plasma cysteine redox potential in critically Ill children.The Journal of steroid biochemistry and molecular biology · 2018Trial
- Metabolic alterations in multiple sclerosis and the impact of vitamin D supplementation.JCI insight · 2017Trial
- Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing-Remitting Multiple Sclerosis.Current issues in molecular biology · 2024Article
- Association of vitamin D status and vitamin D receptor polymorphism in diabetic foot ulcer patients: A prospective observational study in a South-Indian tertiary healthcare facility.International wound journal · 2024Observational
- Vitamin D supplementation and immune-related markers: an update from nutrigenetic and nutrigenomic studies.The British journal of nutrition · 2022Review
- The vitamin D receptor gene variants, ApaI, TaqI, BsmI, and FokI in diabetic foot ulcer and their association with oxidative stress.Molecular biology reports · 2022Article
- Data-Driven Cluster Analysis of Oxidative Stress Indexes in relation to Vitamin D Level, Age, and Metabolic Control in Patients with Type 2 Diabetes on Metformin Therapy.Oxidative medicine and cellular longevity · 2021Article
- Assessing the effect of MitoQHeliyon · 2020Article
- Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials.Diabetology & metabolic syndrome · 2018Article
- Review
- Vitamin D Status and Gestational Diabetes: Effect of Smoking Status during Pregnancy.Paediatric and perinatal epidemiology · 2016Observational
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe objectives were to evaluate the effects of improvement of vitamin D status on biomarkers of oxidative stress (OS) in type 2 diabetic (T2D) subjects and whether vitamin D receptor (VDR)-FokI polymorphisms could modulate the response to vitamin D3 intake. SUBJECTS/
methodsSubjects with T2D were allocated to one of the two groups to receive either plain doogh (PD; containing 150 mg calcium and no vitamin D/250 ml, n1=50) or vitamin D3-fortified doogh (FD; containing 500 IU/250 ml, n1=50) twice a day for 12 weeks. Outcomes were changes in serum 25-hydroxyvitamin D (25(OH)D), superoxide dismutase, glutathione (GSH), total antioxidant capacity (TAC) and malondialdehyde (MDA). VDR genotypes in 140 T2D subjects in FD were determined by FokI restriction enzyme.
resultsAfter 12 weeks, serum 25(OH)D increased significantly in FD (from 38.5±202.2 to 72.0±23.5, P<0.001) as compared with PD (from 38.8±22.8 to 33.4±22.8, P=0.28). Comparisons between FD and PD revealed significant differences in changes of serum MDA (-0.54±0.82 μmol/l vs. +0.17±1 μmol/l, P<0.001), GSH (+8.4±40.1 ng/l vs -13.1±29.4 ng/l, P=0.002) and TAC (+0.14±0.43 mmol/l vs. +0.02±0.45 mmol/l bovine serum albumin equivalent, P=0.03). Although there was no significant association between FokI genotypes and OS biomarkers, ff variant subgroup showed the weakest response to vitamin D.
conclusionsImprovement of vitamin D status via daily intake of FD ameliorates OS biomarkers in T2D subjects and the interactive effect of FokI genotypes cannot be ruled out.
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