Evidence map›Paper›PMID 25424398›Full record

Trial reportDepression and anxiety2015

A randomized controlled trial of cognitive-behavioral therapy versus treatment as usual for adolescents with autism spectrum disorders and comorbid anxiety.

Eric A Storch, Adam B Lewin, Amanda B Collier, Elysse Arnold, Alessandro S De Nadai, Brittney F Dane, Joshua M Nadeau, P Jane Mutch, Tanya K Murphy

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Depression and anxiety, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 10 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 10 syntheses or guidelines pooled it, 138 citations in OpenAlex.

  1. Meta-analysis of Psychotherapy for Autistic Youth.Child psychiatry and human development · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Eric A StorchDepartment of Pediatrics, University of South Florida, St. Petersburg, Florida; Department of Psychiatry & Behavioral Neurosciences, University of South Florida, St. Petersburg, Florida; Rogers Behavioral Health, Tampa Bay, Florida; All Children's Hospital, Johns Hopkins Medicine, St. Petersburg, Florida.
Adam B Lewin
Amanda B Collier
Elysse Arnold
Alessandro S De Nadai
Brittney F Dane
Joshua M Nadeau
P Jane Mutch
Tanya K Murphy
University of South Florida St. Petersburg · USJohns Hopkins All Children's Hospital · USJohns Hopkins University · USRogers Behavioral Health · US

Funding

Alliance and Mechanisms of Medication Adherence in Pediatric Psychiatric PracticeF31MH094095 · NIMH · UNIVERSITY OF SOUTH FLORIDA · PI DE NADAI, ALESSANDRO STEVENS · 2013 to 2014
$69k
NIMH NIH HHS F31 MH094095
6 · The paper itself

Abstract

objectiveExamine the efficacy of a personalized, modular cognitive-behavioral therapy (CBT) protocol among early adolescents with high-functioning autism spectrum disorders (ASDs) and co-occurring anxiety relative to treatment as usual (TAU).

methodThirty-one children (11-16 years) with ASD and clinically significant anxiety were randomly assigned to receive 16 weekly CBT sessions or an equivalent duration of TAU. Participants were assessed by blinded raters at screening, posttreatment, and 1-month follow-up.

resultsYouth randomized to CBT demonstrated superior improvement across primary outcomes relative to those receiving TAU. Eleven of 16 adolescents randomized to CBT were treatment responders, versus 4 of 15 in the TAU condition. Gains were maintained at 1-month follow-up for CBT responders.

conclusionsThese data extend findings of the promising effects of CBT in anxious youth with ASD to early adolescents.

Indexed as

Cognitive Behavioral TherapyAdolescentAnxietyAnxiety DisordersAutism Spectrum DisorderChildComorbidityFemaleHumansMaleTreatment Outcomeadolescentsanxietyautism spectrum disordercognitive-behavioral therapyobsessive-compulsive disorder

Identifiers

PMID25424398
PMCPMC4346416
OpenAlexW2164189797

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.