ArticlePlant physiology2015
Two cytoplasmic effectors of Phytophthora sojae regulate plant cell death via interactions with plant catalases.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 162 citations in OpenAlex.
- Systematic Identification and Functional Characterisation of Colletotrichum fructicola Effectors During Camellia oleifera Colonisation.Molecular plant pathology · 2026Article
- An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The StABI5-Biology · 2026Article
- From triangle to pyramid: Understanding host-pathogen-microniome-environment interplay for sustainable, enviromics-empowered management of plant diseases.Plant communications · 2026Review
- The Fusarium sacchari Effector FsP4H1 Targets the Transcription Factor DPb to Disrupt Catalase-Mediated HMolecular plant pathology · 2026Article
- Emerging concepts of reactive oxygen species functions in plants.Biochemical Society transactions · 2026Review
- Effector-Mediated Spatial Reprogramming of Glycolate Oxidase Subverts Peroxisomal and Membrane-Associated ROS Defences.Plant biotechnology journal · 2026Article
- Oomycete plant pathogens: biology, pathogenesis and emerging control strategies.Nature reviews. Microbiology · 2026Review
- The virulence function of RXLR effectorVirulence · 2025Article
- Peroxisomal-dependent signalling and dynamics modulate plant stress responses: reactive oxygen and nitrogen species as key molecules.Journal of experimental botany · 2025Review
- Redox regulation of LSD1/CATALASE 2 phase separation condensates controls location and functions.The New phytologist · 2025Article
- A conserved fungal effector disturbs CaNature communications · 2025Article
- Tomato Biostimulation with Nanochitosan-Iodine Complexes: Enhancing Antioxidant Metabolism.Plants (Basel, Switzerland) · 2025Article
- EffectorFrontiers in microbiology · 2025Article
- The levels of pattern-triggered immunity in the root and stembase of tomato cultivars positively correlate with the resistance to Ralstonia solanacearum.Botanical studies · 2024Article
- Photorespiratory Metabolism and Its Regulatory Links to Plant Defence Against Pathogens.International journal of molecular sciences · 2024Review
- Effector CLas0185 targets methionine sulphoxide reductase B1 of Citrus sinensis to promote multiplication of 'Candidatus Liberibacter asiaticus' via enhancing enzymatic activity of ascorbate peroxidase 1.Molecular plant pathology · 2024Article
- Root-knot nematodes exploit the catalase-like effector to manipulate plant reactive oxygen species levels by directly degrading HMolecular plant pathology · 2024Article
- Superoxide signalling and antioxidant processing in the plant nucleus.Journal of experimental botany · 2024Review
- Identification of Phytophthora cinnamomi CRN effectors and their roles in manipulating cell death during Persea americana infection.BMC genomics · 2024Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant pathogenic oomycetes, such as Phytophthora sojae, secrete an arsenal of host cytoplasmic effectors to promote infection. We have shown previously that P. sojae PsCRN63 (for crinkling- and necrosis-inducing proteins) induces programmed cell death (PCD) while PsCRN115 blocks PCD in planta; however, they are jointly required for full pathogenesis. Here, we find that PsCRN63 alone or PsCRN63 and PsCRN115 together might suppress the immune responses of Nicotiana benthamiana and demonstrate that these two cytoplasmic effectors interact with catalases from N. benthamiana and soybean (Glycine max). Transient expression of PsCRN63 increases hydrogen peroxide (H(2)O(2)) accumulation, whereas PsCRN115 suppresses this process. Transient overexpression of NbCAT1 (for N. benthamiana CATALASE1) or GmCAT1 specifically alleviates PsCRN63-induced PCD. Suppression of the PsCRN63-induced PCD by PsCRN115 is compromised when catalases are silenced in N. benthamiana. Interestingly, the NbCAT1 is recruited into the plant nucleus in the presence of PsCRN63 or PsCRN115; NbCAT1 and GmCAT1 are destabilized when PsCRN63 is coexpressed, and PsCRN115 inhibits the processes. Thus, PsCRN63/115 manipulates plant PCD through interfering with catalases and perturbing H(2)O(2) homeostasis. Furthermore, silencing of catalase genes enhances susceptibility to Phytophthora capsici, indicating that catalases are essential for plant resistance. Taken together, we suggest that P. sojae secretes these two effectors to regulate plant PCD and H(2)O(2) homeostasis through direct interaction with catalases and, therefore, overcome host immune responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.