ArticleDigestive diseases and sciences2015
Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population.
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Associations of CYP2B6 genetic polymorphisms with Hirschsprung's disease in a southern Chinese population.Journal of clinical laboratory analysis · 2021Article
- CYP2B6 Polymorphisms Are Associated with Ischemic Stroke Risk in a Chinese Han Population.Journal of molecular neuroscience : MN · 2020Article
- Hirschsprung's disease: clinical dysmorphology, genes, micro-RNAs, and future perspectives.Pediatric research · 2017Review
- Suppressive action of miRNAs to ARP2/3 complex reduces cell migration and proliferation via RAC isoforms in Hirschsprung disease.Journal of cellular and molecular medicine · 2016Article
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11 authors.
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Abstract
backgroundPrevious studies suggested that cytochrome P450 participated in the tumor metastasis and migration. CYP2B6 also acts as an important enzyme which metabolize partially or primarily metabolism of drugs, environmental contaminants, and mutagens. The objective of this study was to investigate the influence of CYP2B6 polymorphism on susceptibility of Hirschsprung disease.
methodsTaqMan assay was performed to determine the genotypes of CYP2B6 rs707265, rs1042389, rs2054675 in 262 cases and 290 control subjects. Logistic regression was used to assess the associations between these polymorphisms and HSCR.
resultsWe observed a significant association of CYP2B6 rs707265 (G>A) polymorphism and HSCR susceptibility (p < 0.001). Besides, rs707265 A presented a significant risk of HSCR (p < 0.001).
conclusionsOur result suggested that CYP2B6 rs707265 modified the risk of HSCR.
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