Trial reportNature communications2014
Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding.
Trial report in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Brain regions that show repetition suppression and enhancement: A meta-analysis of 137 neuroimaging experiments.Human brain mapping · 2017Pooled it
- Trial
- Functional Imaging of Hippocampal Layers Using VASO and BOLD on the Next Generation (NexGen) 7T Scanner.Human brain mapping · 2026Article
- Functional MRI of the Human Hippocampus at 10.5T: Pushing the Boundaries of Spatial Resolution.bioRxiv : the preprint server for biology · 2026Article
- The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance.Human brain mapping · 2026Article
- Peripheral inflammation mediates cognitive deficits in drug-naive schizophrenia through hippocampal-thalamo-visual circuitry dysfunction.Schizophrenia (Heidelberg, Germany) · 2026Article
- Toward brain-trained humanoid robots.Frontiers in neurorobotics · 2026Article
- Complementary roles of the human perirhinal and the entorhinal cortex in the hippocampal retrieval of episodic memory.iScience · 2025Article
- Functional imaging of hippocampal layers using VASO and BOLD on the Next Generation (NexGen) 7T Scanner.bioRxiv : the preprint server for biology · 2025Article
- Blood volume sensitive laminar fMRI with VASO in human hippocampus: Capabilities and biophysical challenges at clinical 7T scanners.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal subfields in aging: Sex-specific trajectories in structure and hemodynamics.NeuroImage · 2025Article
- Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex.Science advances · 2025Article
- Hippocampus shapes entorhinal cortical output through a direct feedback circuit.Nature neuroscience · 2025Article
- Characterizing BOLD activation patterns in the human hippocampus with laminar fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.Current topics in behavioral neurosciences · 2025Review
- Emotional salience network involved in constructing two-dimensional fear space in humans.Neurobiology of stress · 2025Review
- Insights into hippocampal perfusion using high-resolution, multi-modal 7T MRI.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cerebral hyperactivation across the Alzheimer's disease pathological cascade.Brain communications · 2024Review
- Hippocampal subfields and their neocortical interactions during autobiographical memory.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Entorhinal cortex-hippocampal circuit connectivity in health and disease.Frontiers in human neuroscience · 2024Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
The ability to form long-term memories for novel events depends on information processing within the hippocampus (HC) and entorhinal cortex (EC). The HC-EC circuitry shows a quantitative segregation of anatomical directionality into different neuronal layers. Whereas superficial EC layers mainly project to dentate gyrus (DG), CA3 and apical CA1 layers, HC output is primarily sent from pyramidal CA1 layers and subiculum to deep EC layers. Here we utilize this directionality information by measuring encoding activity within HC/EC subregions with 7 T high resolution functional magnetic resonance imaging (fMRI). Multivariate Bayes decoding within HC/EC subregions shows that processing of novel information most strongly engages the input structures (superficial EC and DG/CA2-3), whereas subsequent memory is more dependent on activation of output regions (deep EC and pyramidal CA1). This suggests that while novelty processing is strongly related to HC-EC input pathways, the memory fate of a novel stimulus depends more on HC-EC output.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.