Evidence map›Paper›PMID 25423647›Full record

ArticleIEEE transactions on bio-medical engineering2015

Multimodal neuroimaging feature learning for multiclass diagnosis of Alzheimer's disease.

Siqi Liu, Sidong Liu, Weidong Cai, Hangyu Che, Sonia Pujol, Ron Kikinis, Dagan Feng, Michael J Fulham, ADNI

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 3 pooled it
29.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 3 syntheses or guidelines pooled it, 608 citations in OpenAlex.

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  15. Interpretable Alzheimer's Diagnosis via Multimodal Fusion of Regional Brain Experts.Proceedings. IEEE International Conference on Healthcare Informatics · 2026
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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Siqi Liu
Sidong Liu
Weidong Cai
Hangyu Che
Sonia Pujol
Ron Kikinis
Dagan Feng
Michael J Fulham
ADNI
Brigham and Women's Hospital · USThe University of Sydney · AU

Funding

Washington University ConsoritumU54EB005149 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON · 2004 to 2013
$39.3M
WHITE MATTER ARCHITECTURE FROM DT-MRIP41RR013218 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON · 1998 to 2011
$30.6M
Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON, WESTIN, CARL-FREDRIK · 2012 to 2022
$20.9M
NCRR NIH HHS P41 RR013218NIBIB NIH HHS P41 EB015902NIBIB NIH HHS P41EB015902NIBIB NIH HHS U54 EB005149NIBIB NIH HHS U54EB005149
6 · The paper itself

Abstract

The accurate diagnosis of Alzheimer's disease (AD) is essential for patient care and will be increasingly important as disease modifying agents become available, early in the course of the disease. Although studies have applied machine learning methods for the computer-aided diagnosis of AD, a bottleneck in the diagnostic performance was shown in previous methods, due to the lacking of efficient strategies for representing neuroimaging biomarkers. In this study, we designed a novel diagnostic framework with deep learning architecture to aid the diagnosis of AD. This framework uses a zero-masking strategy for data fusion to extract complementary information from multiple data modalities. Compared to the previous state-of-the-art workflows, our method is capable of fusing multimodal neuroimaging features in one setting and has the potential to require less labeled data. A performance gain was achieved in both binary classification and multiclass classification of AD. The advantages and limitations of the proposed framework are discussed.

Indexed as

Alzheimer DiseaseBrainHumansImage Interpretation, Computer-AssistedMultimodal ImagingNeuroimagingSupport Vector Machine

Identifiers

PMID25423647
PMCPMC4394860
OpenAlexW2130371234

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.