Evidence map›Paper›PMID 25423620›Full record

ArticleBiochemistry2014

The rate-limiting step of O2 activation in the α-ketoglutarate oxygenase factor inhibiting hypoxia inducible factor.

John A Hangasky, Hasand Gandhi, Meaghan A Valliere, Nathaniel E Ostrom, Michael J Knapp

Abstract read
In one paragraph

Article in Biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Spectroscopic and in vitro Investigations of FeChembiochem : a European journal of chemical biology · 2022
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John A HangaskyDepartment of Chemistry, University of Massachusetts , Amherst, Massachusetts 01003, United States.
Hasand Gandhi
Meaghan A Valliere
Nathaniel E Ostrom
Michael J Knapp

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Molecular mechanisms of hypoxia sensing by the HIF-hydroxylasesR01GM077413 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI KNAPP, MICHAEL J · 2007 to 2018
$2.2M
NIGMS NIH HHS 1R01-GM077413NIGMS NIH HHS T32 GM008515NIGMS NIH HHS T32-GM008515
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HumansKetoglutaric AcidsKineticsMixed Function OxygenasesModels, BiologicalMutagenesis, Site-DirectedOxygenOxygen IsotopesPeptide FragmentsProtein Structure, TertiaryRecombinant ProteinsRepressor ProteinsSolventsViscosityHIF1AN protein, humanKetoglutaric AcidsMixed Function OxygenasesOxygenOxygen IsotopesPeptide FragmentsRecombinant ProteinsRepressor ProteinsSolvents

Identifiers

PMID25423620
PMCPMC4283935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.