ArticlePloS one2014
Is nephrolithiasis an unrecognized extra-articular manifestation in ankylosing spondylitis? A prospective population-based Swedish national cohort study with matched general population comparator subjects.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Prevalence and risk factors of renal involvement in seronegative spondyloarthropathies: a systematic review.Rheumatology international · 2025Pooled it
- [Long version on the S3 guidelines for axial spondyloarthritis including Bechterew's disease and early forms, Update 2019 : Evidence-based guidelines of the German Society for Rheumatology (DGRh) and participating medical scientific specialist societies and other organizations].Zeitschrift fur Rheumatologie · 2019Guideline
- Body fatness, diabetes, physical activity and risk of kidney stones: a systematic review and meta-analysis of cohort studies.European journal of epidemiology · 2018Pooled it
- Evidence for nephrolithiasis preceding sarcoidosis diagnosis: findings from a Swedish case-control study.Respiratory research · 2026Article
- Ankylosing spondylitis: an independent risk factor for nephrolithiasis and the prognostic value of follow-up CT.Abdominal radiology (New York) · 2026Article
- Renal involvement in ankylosing spondylitis: a retrospective, population-based cohort study using data from the TriNetX Global Network.RMD open · 2026Article
- The effect of narrow costovertebral angle on percutaneous nephrolithotomy outcomes.Urolithiasis · 2025Article
- Non-steroidal anti-inflammatory drugs and risk of kidney cancer: A Swedish nationwide cohort study in the general and high-use populations.Journal of internal medicine · 2025Article
- Risks of solid cancers in elderly persons with osteoarthritis or ankylosing spondylitis.Rheumatology (Oxford, England) · 2020Article
- Nephrolithiasis in ankylosing spondylitis and its relationship with disease assessment scales.Northern clinics of Istanbul · 2019Article
- Spondyloarthritis Patients Suffer Increased Risk of Renal Complications Compared With General Population: A Retrospective Observational Study.Frontiers in pharmacology · 2019Article
- Urolithiasis as an extraarticular manifestation of ankylosing spondylitis.Rheumatology international · 2017Review
- Risk factors for urolithiasis in patients with ankylosing spondylitis: a prospective case-control study.Urolithiasis · 2017Article
- Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort study.Arthritis research & therapy · 2017Article
- Observational
- The Risk of Nephrolithiasis Among Patients With Ankylosing Spondylitis: a Population-Based Cohort Study.Archives of rheumatology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnkylosing spondylitis (AS) is associated with several extra-articular manifestations. Nephrolithiasis (NL) has not been recognized as one of those, however, several factors known to increase the risk of NL are at play in AS patients. The objective was to estimate rates and predictors of NL in Swedish patients with AS compared to the general population. METHODS AND
findingsWe performed a prospective population-based nationwide cohort study based on linkage of data from Swedish registries. 8,572 AS patients were followed for 49,258 person-years (py) and 39,639 matched general population comparators were followed for 223,985 py. Patients were followed prospectively together with comparator subjects from January 2001 through December 2009. The first occurrence of NL during follow-up was the primary outcome. Hazard Ratios (HR) were used to compare these rates adjusting for comorbidities and treatment, and to assess predictors for NL. Mean age at study entry was 46 years (inter quartile range 36-56 years), 65% were males. Based on 250 vs. 466 NL events, the adjusted HR of NL in AS patients was 2.1 (95%CI 1.8 to 2.4). Predictors of NL within the AS group included prior diagnosis of inflammatory bowel disease (IBD) (HR 2.3; 95%CI 1.7 to 3.3), prior diagnosis of NL (HR 16.4; 95%CI 11.5 to 23.4), and patients receiving anti-TNF treatment (HR 1.6; 95%CI 1.2 to 2.1). Male sex was a risk factor for NL both in AS patients and in the general population. LIMITATIONS: The risk for residual confounding and inability to study the chemical nature of NL were considered the main limitations of the study.
conclusionsPatients with AS are at increased risk of NL, which may be considered a novel extra-articular manifestation. Previous history of NL, IBD, AS disease severity and male sex were identified as predictors of NL in AS.
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