ArticlePloS one2014
The burden of disease and health care use among pertussis cases in school aged children and adults in England and Wales; a patient survey.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Under-recognized pertussis in adults from Asian countries: a cross-sectional seroprevalence study in Malaysia, Taiwan and Thailand.Epidemiology and infection · 2016Trial
- Review
- Understanding the impact of adult pertussis and current approaches to vaccination: A narrative review and expert panel recommendations.Human vaccines & immunotherapeutics · 2024Review
- Burden of Pertussis in Adults Aged 50 Years and Older: A Retrospective Database Study in England.Infectious diseases and therapy · 2023Article
- Pertussis in Individuals with Co-morbidities: A Systematic Review.Infectious diseases and therapy · 2021Review
- Article
- Vaccination Programs for Adults in Europe, 2019.Vaccines · 2020Article
- Decision-making on maternal pertussis vaccination among women in a vaccine-hesitant religious group: Stages and needs.PloS one · 2020Article
- Is adding maternal vaccination to prevent whooping cough cost-effective in Australia?Human vaccines & immunotherapeutics · 2018Article
- Risk factors for pertussis in adults and teenagers in England.Epidemiology and infection · 2017Article
- Estimated incidence of pertussis in people aged <50 years in the United States.Human vaccines & immunotherapeutics · 2016Article
- Investigating the pertussis resurgence in England and Wales, and options for future control.BMC medicine · 2016Article
- Pertussis: Microbiology, Disease, Treatment, and Prevention.Clinical microbiology reviews · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn 2011-2012 a large pertussis outbreak occurred in England. This provided an opportunity to estimate the disease burden in those aged 5 years and over. As pertussis is likely to be under reported both laboratory-confirmed and non-confirmed cases were included.
methodsLaboratory-confirmed cases of pertussis, as well as their coughing but non-confirmed household members, were sent a questionnaire that collected information on clinical features and quality of life for the most severe day of disease and the day the patient filled in the questionnaire. The EuroQol-5 dimension questionnaire (EQ-5D) was used to evaluate quality of life. The duration of symptoms was obtained by contacting the patient every two weeks until symptoms stopped.
resultsData for 535 (out of 1262) laboratory confirmed pertussis patients and 44 (out of 140) coughing household contacts was available for analysis. On the most severe day, 56% of laboratory-confirmed cases reported they had 20+ more paroxysms, 58% reported they had a severe cough and 46% reported disruption of sleep for more than 4 hours. For non-confirmed coughing household contacts there were a similar number of coughing spells per day at the height, though the cough was reported to be less severe and to cause less sleep disruption. The main clinical symptoms on the worst day for both were shortness of breath, tiredness, sore ribs and vomiting. The duration of symptoms for both patient groups was around 160 days (162 and 168 days). Under base case assumptions the overall loss of quality of life was 0.097 QALY (0.089-0.106) for confirmed pertussis cases and 0.0365 QALY (0.023-0.054) for coughing household contacts.
conclusionPertussis is a serious disease in those aged 5 years and over, causing disruption of sleep and daily activities over long period of time. The burden of illness due to undiagnosed pertussis is also considerable.
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