ArticleDevelopment and psychopathology2014
Premorbid risk factors for major depressive disorder: are they associated with early onset and recurrent course?
Article in Development and psychopathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Depression in youths with early life adversity: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Are depressive disorders caused by psychosocial stressors at work? A systematic review with metaanalysis.European journal of epidemiology · 2021Pooled it
- Meta-analysis: Exposure to Early Life Stress and Risk for Depression in Childhood and Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Pooled it
- Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group.Molecular psychiatry · 2017Pooled it
- Genetic risk-dependent brain markers of resilience to childhood Trauma.Nature communications · 2025Article
- Depressive disorders in children: recent prevalence and future directions.Evidence-based nursing · 2025Article
- Preonset predictors of chronic-intermittent depression from early adolescence to early adulthood.Journal of psychopathology and clinical science · 2023Article
- Effects of mental health stigma on loneliness, social isolation, and relationships in young people with depression symptoms.BMC psychiatry · 2023Article
- Personality traits among major depressive disorder in southern Thailand: a hospital-based case-control study.BMC psychology · 2023Article
- Familial Risk Factors in Relation to Recurrent Depression Among Former Adolescent Psychiatric Inpatients.Child psychiatry and human development · 2022Article
- Environmental factors in offspring of parents with mood disorders and their role in parent-child transmission: findings from a 14-year prospective high-risk study.International journal of bipolar disorders · 2022Article
- Myofascial Tissue and Depression.Cognitive therapy and research · 2022Article
- Multiple domains of risk factors for first onset of depression in adolescent girls.Journal of affective disorders · 2021Article
- Investigation of Effects of Two Chronic Stress Protocols on Depression-Like Behaviors and Brain Mineral Levels in Female Rats: an Evaluation of 7-Day Immobilization Stress.Biological trace element research · 2021Article
- Incorporating family factors into treatment planning for adolescent depression: Perceived parental criticism predicts longitudinal symptom trajectory in the Youth Partners in Care trial.Journal of affective disorders · 2021Article
- Role of Ketamine in the Treatment of Psychiatric Disorders.Health psychology research · 2021Review
- Childhood Maltreatment Was Correlated With the Decreased Cortical Function in Depressed Patients Under Social Stress in a Working Memory Task: A Pilot Study.Frontiers in psychiatry · 2021Article
- Precision Psychiatry: Biomarker-Guided Tailored Therapy for Effective Treatment and Prevention in Major Depression.Advances in experimental medicine and biology · 2021Review
- Early pubertal timing predicts onset and recurrence of depressive episodes in boys and girls.Journal of child psychology and psychiatry, and allied disciplines · 2020Article
- Consequences of Recurrence of Major Depressive Disorder: Is Stopping Effective Antidepressant Medications Ever Safe?Focus (American Psychiatric Publishing) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Premorbid risk for major depressive disorder (MDD) and predictors of an earlier onset and recurrent course were examined in two studies in a large, community-based sample of parents and offspring, prospectively assessed from late childhood into adulthood. In Study 1 (N = 2,764 offspring and their parents), parental psychiatric status, offspring personality at age 11, and age 11 offspring internalizing and externalizing symptoms predicted the subsequent development of MDD, as did poor quality parent-child relationships, poor academic functioning, early pubertal development, and childhood maltreatment by age 11. Parental MDD and adult antisocial behavior, offspring negative emotionality and disconstraint, externalizing symptoms, and childhood maltreatment predicted an earlier onset of MDD, after accounting for course; lower positive emotionality, trait anxiety, and childhood maltreatment predicted recurrent MDD, after accounting for age of onset. In Study 2 (N = 7,146), we examined molecular genetic risk for MDD by extending recent reports of associations with glutamatergic system genes. We failed to confirm associations with MDD using either individual single nucleotide polymorphism based tests or gene-based analyses. Overall, results speak to the pervasiveness of risk for MDD, as well as specific risk for early onset MDD; risk for recurrent MDD appears to be largely a function of its often earlier onset.
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Registered trials
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