ArticleDevelopment and psychopathology2014
Atypical patterns of respiratory sinus arrhythmia index an endophenotype for depression.
Article in Development and psychopathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Atypical reactivity of heart rate variability to stress and depression across development: Systematic review of the literature and directions for future research.Clinical psychology review · 2016Pooled it
- Effects of working memory training on cognitive, affective, and biological responses to stress in major depression: A novel cognitive bias modification protocol.Journal of affective disorders · 2020Trial
- Neurophysiological Markers of Regulation Success in Everyday Life in Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Childhood Family Stress and Women's Health: Parasympathetic Activity as a Risk and Resiliency Factor.Applied psychophysiology and biofeedback · 2024Article
- Integrating dynamic psychophysiological indices across time and contexts: Elucidating mechanisms, risk markers, and intervention targets.Psychophysiology · 2024Review
- Autonomic Inertia as a Proximal Risk Marker for Moments of Perseverative Cognition in Everyday Life in Remitted Depression.Depression and anxiety · 2024Article
- Long-term stability of respiratory sinus arrhythmia among adults with and without a history of depression.Psychophysiology · 2024Article
- Effects of current and past depressive episodes on behavioral performance and subjective experience during an N-back task.Journal of behavior therapy and experimental psychiatry · 2023Article
- Autonomic complexity dynamically indexes affect regulation in everyday life.Journal of psychopathology and clinical science · 2023Article
- Examining the Relations Between Children's Vagal Flexibility Across Social Stressor Tasks and Parent- and Clinician-Rated Anxiety Using Baseline Data from an Early Intervention for Inhibited Preschoolers.Research on child and adolescent psychopathology · 2023Article
- Maternal Mental Health and Parenting Stress and Their Relationships to Characteristics of the Child With Fragile X Syndrome.Frontiers in psychiatry · 2021Article
- Inflexible autonomic responses to sadness predict habitual and real-world rumination: A multi-level, multi-wave study.Biological psychology · 2020Article
- Using ambulatory assessment to measure dynamic risk processes in affective disorders.Journal of affective disorders · 2019Review
- Adversity and Depression: The Moderating Role of Stress Reactivity among High and Low Risk Youth.Journal of abnormal child psychology · 2019Article
- Associations of depression severity with heart rate and heart rate variability in young adults across normative and clinical populations.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019Article
- Autonomic correlates of lifetime suicidal thoughts and behaviors among adolescents with a history of depression.Psychophysiology · 2019Article
- Non-response to sad mood induction: implications for emotion research.Cognition & emotion · 2018Article
- Cardiac vagal dysfunction moderates patterns of craving across the day in moderate to heavy consumers of alcohol.PloS one · 2018Article
- Childhood adversity predicts reduced physiological flexibility during the processing of negative affect among adolescents with major depression histories.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Perseverate or decenter? Differential effects of metacognition on the relationship between parasympathetic inflexibility and symptoms of depression in a multi-wave study.Behaviour research and therapy · 2017Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Can atypical patterns of parasympathetic nervous system activity serve as endophenotypes for depression? Using respiratory sinus arrhythmia (RSA) as an index of parasympathetic nervous system function, we examined this question in two studies: one involving mothers with and without depression histories and their offspring (at high and low risk for depression, respectively), and a further study of adolescent sibling pairs concordant and discordant for major depression. In both studies, subjects were exposed to sad mood induction; subjects' RSA was monitored during rest periods and in response to the mood induction. We used Gottesman and Gould's (2003) criteria for an endophenotype and a priori defined "atypical" and "normative" RSA patterns (combinations of resting RSA and RSA reactivity). We found that atypical RSA patterns (a) predicted current depressive episodes and remission status among women with histories of juvenile onset depression and healthy controls, (b) predicted longitudinal trajectories of depressive symptoms among high- and low-risk young offspring, (c) were concordant across mothers and their juvenile offspring, (d) were more prevalent among never-depressed youth at high risk for depression than their low-risk peers, and (e) were more concordant across adolescent sibling pairs in which both versus only one had a history of major depression. Thus, the results support atypical RSA patterns as an endophenotype for depression. Possible mechanisms by which RSA patterns increase depression risk and their genetic contributors are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.