ArticleDevelopment and psychopathology2014
Multilevel assessment of the neurobiological threat system in depressed adolescents: interplay between the limbic system and hypothalamic-pituitary-adrenal axis.
Article in Development and psychopathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortisol and development of depression in adolescence and young adulthood - a systematic review and meta-analysis.Psychoneuroendocrinology · 2022Pooled it
- Predicting stress response trajectories: Differential contributions of limbic and prefrontal regions to cortisol and affective responses.Translational psychiatry · 2026Article
- Linking brain structure to stress reactivity: cingulate surface area predicts acute cortisol responses.Psychological medicine · 2026Article
- Cortisol and C-reactive protein interact to predict depressive symptoms.Psychoneuroendocrinology · 2026Article
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neonatal amygdala volumes, procedural pain and the association with social-emotional development in children born very preterm.Brain structure & function · 2024Article
- Stress system concordance as a predictor of longitudinal patterns of resilience in adolescence.Development and psychopathology · 2023Article
- A Multilevel Examination of Cognitive Control in Adolescents With Nonsuicidal Self-injury.Biological psychiatry global open science · 2023Article
- Article
- Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.Translational psychiatry · 2023Article
- In(s) and out(s) of adolescent depression - Trajectories of development and recovery.Brain, behavior, & immunity - health · 2021Article
- Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury.Development and psychopathology · 2021Article
- Stress-induced cortisol response is associated with right amygdala volume in early childhood.Neurobiology of stress · 2021Article
- Coordination between frontolimbic resting state connectivity and hypothalamic-pituitary-adrenal axis functioning in adolescents with and without depression.Psychoneuroendocrinology · 2021Article
- Pre-scan cortisol is differentially associated with enhanced connectivity to the cognitive control network in young adults with a history of depression.Psychoneuroendocrinology · 2019Article
- Comparing stress and arousal systems in response to different social contexts in children with ASD.Biological psychology · 2019Article
- Increases in orbitofrontal cortex thickness following antidepressant treatment are associated with changes in resting state autonomic function in adolescents with major depression - Preliminary findings from a pilot study.Psychiatry research. Neuroimaging · 2018Article
- Brain structural thickness and resting state autonomic function in adolescents with major depression.Social cognitive and affective neuroscience · 2018Article
- Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress.Psychoneuroendocrinology · 2017Article
- Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Integrative, multilevel approaches investigating neurobiological systems relevant to threat detection promise to advance understanding of the pathophysiology of major depressive disorder (MDD). In this study we considered key neuronal and hormonal systems in adolescents with MDD and healthy controls (HC). The goals of this study were to identify group differences and to examine the association of neuronal and hormonal systems. MDD and HC adolescents (N = 79) aged 12-19 years were enrolled. Key brain measures included amygdala volume and amygdala activation to an emotion face-viewing task. Key hormone measures included cortisol levels during a social stress task and during the brain scan. MDD and HC adolescents showed group differences on amygdala functioning and patterns of cortisol levels. Amygdala activation in response to emotional stimuli was positively associated with cortisol responses. In addition, amygdala volume was correlated with cortisol responses, but the pattern differed in depressed versus healthy adolescents, most notably for unmedicated MDD adolescents. The findings highlight the value of using multilevel assessment strategies to enhance understanding of pathophysiology of adolescent MDD, particularly regarding how closely related biological threat systems function together while undergoing significant developmental shifts.
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