Evidence map›Paper›PMID 25422760›Full record

ArticleJournal of diabetes investigation2014

Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage.

Quan Liu, Shudong Wang, Lu Cai

Open access · goldAbstract read
In one paragraph

Article in Journal of diabetes investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 201 citations in OpenAlex.

  1. A Computational Model of Oxidative Stress in a Human Ventricular Myocyte.bioRxiv : the preprint server for biology · 2026
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Quan LiuCenter of Cardiovascular Diseases at the First Hospital of the Jilin University Changchun, China.
Shudong WangCenter of Cardiovascular Diseases at the First Hospital of the Jilin University Changchun, China ; Kosair Children's Hospital Research Institute, the Department of Pediatrics, the University of Louisville Louisville, KY, USA.
Lu CaiKosair Children's Hospital Research Institute, the Department of Pediatrics, the University of Louisville Louisville, KY, USA ; Departments of Radiation Oncology, Pharmacology and Toxicology, the University of Louisville Louisville, KY, USA.
First Hospital of Jilin University · CNKosair Children's Hospital · USUniversity of Louisville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic cardiomyopathy as an important threat to health occurs with or without coexistence of vascular diseases. The exact mechanisms underlying the disease remain incompletely clear. Although several pathological mechanisms responsible for diabetic cardiomyopathy have been proposed, oxidative stress is widely considered as one of the major causes for the pathogenesis of the disease. Hyperglycemia-, hyperlipidemia-, hypertension- and inflammation-induced oxidative stress are major risk factors for the development of microvascular pathogenesis in the diabetic myocardium, which results in abnormal gene expression, altered signal transduction and the activation of pathways leading to programmed myocardial cell deaths. In the present article, we aim to provide an extensive review of the role of oxidative stress and anti-oxidants in diabetic cardiomyopathy based on our own works and literature information available.

Indexed as

Anti-oxidantsDiabetic cardiomyopathyOxidative stress

Identifiers

PMID25422760
PMCPMC4234223
OpenAlexW2029800273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.