Evidence map›Paper›PMID 25422678›Full record

ArticleCurrent protocols in bioinformatics2013

STRAP PTM: Software Tool for Rapid Annotation and Differential Comparison of Protein Post-Translational Modifications.

Jean L Spencer, Vivek N Bhatia, Stephen A Whelan, Catherine E Costello, Mark E McComb

Abstract readComparative Study
In one paragraph

Article in Current protocols in bioinformatics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan.Matrix biology : journal of the International Society for Matrix Biology · 2017
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jean L SpencerCardiovascular Proteomics Center, Boston University School of Medicine, Boston, MA 02118-2526, USA.
Vivek N BhatiaCardiovascular Proteomics Center, Boston University School of Medicine, 670 Albany Street, Room 504, Boston, MA 02118-2526.
Stephen A WhelanCardiovascular Proteomics Center, Boston University School of Medicine, 670 Albany Street, Room 504, Boston, MA 02118-2526.
Catherine E CostelloCardiovascular Proteomics Center, Boston University School of Medicine, 670 Albany Street, Room 507, Boston, MA 02118-2526.
Mark E McCombCardiovascular Proteomics Center, Boston University School of Medicine, 670 Albany Street, Room 511, Boston, MA 02118-2526.

Funding

XI INTERNATIONAL SYMPOSIUM ON AMYLOIDOSISP41RR010888 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 1996 to 2011
$18.6M
Mass Spectrometry Resource for Biology and MedicineP41GM104603 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2017
$10.4M
MALDI-TOF/TOF MS TO SUPPORT BIOMEDICAL RESEARCHS10OD010724 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2012
$590k
LTQ MASS SPECTROMETER: STRUCTURAL BIOLOGYS10RR020946 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 2006 to 2006
$497k
Protein biomarkers of pulmonary hypertension in sickle cell diseaseR21HL107993 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KLINGS, ELIZABETH S, MCCOMB, MARK E · 2012 to 2013
$440k
STRUCTURAL CHARACTERIZATION OF THE APOPROTEIN E RECEPTORR01HL028178 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI INNERARITY, THOMAS L. · 1986 to 1988
–
NHLBI PROTEOMICS INITIATIVE-N01HV28178N01HV028178 · HV · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2002 to 2006
–
NCRR NIH HHS P41 RR010888NCRR NIH HHS P41 RR010888/NCRR NIH HHS S10 RR020946NHLBI NIH HHS HHSN268201000031CNHLBI NIH HHS N01 HV028178NHLBI NIH HHS R21 HL107993NIGMS NIH HHS GM104603NIGMS NIH HHS P41 GM104603NIH HHS S10 OD010724
6 · The paper itself

Abstract

The identification of protein post-translational modifications (PTMs) is an increasingly important component of proteomics and biomarker discovery, but very few tools exist for performing fast and easy characterization of global PTM changes and differential comparison of PTMs across groups of data obtained from liquid chromatography-tandem mass spectrometry experiments. STRAP PTM (Software Tool for Rapid Annotation of Proteins: Post-Translational Modification edition) is a program that was developed to facilitate the characterization of PTMs using spectral counting and a novel scoring algorithm to accelerate the identification of differential PTMs from complex data sets. The software facilitates multi-sample comparison by collating, scoring, and ranking PTMs and by summarizing data visually. The freely available software (beta release) installs on a PC and processes data in protXML format obtained from files parsed through the Trans-Proteomic Pipeline. The easy-to-use interface allows examination of results at protein, peptide, and PTM levels, and the overall design offers tremendous flexibility that provides proteomics insight beyond simple assignment and counting.

Indexed as

Molecular Sequence AnnotationProtein Processing, Post-TranslationalSoftwareAmino Acid SequenceHumansMolecular Sequence DataPeptidesTandem Mass SpectrometryPeptidesbiomarkersmass spectrometryPost-Translational ModificationsproteomicsPTMssoftwarespectral counting

Identifiers

PMID25422678
PMCPMC4240648

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.