ArticlePharmacognosy magazine2014
Hplc-ESI-MS/MS analysis of the water-soluble extract from Ziziphi spinosae semen and its ameliorating effect of learning and memory performance in mice.
Article in Pharmacognosy magazine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Effects of aerobic exercise and dietary flavonoids on cognition: a systematic review and meta-analysis.Frontiers in physiology · 2023Pooled it
- Correlational and Molecular Mechanism Analyses of Bioactive Compounds FromFood science & nutrition · 2026Article
- Decoding multicomponent crosstalk: integrated pharmacodynamic‒pharmacokinetic network of sour jujube seed.Chinese medicine · 2025Review
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- Comparative Analysis of the Sedative and Hypnotic Effects among Various Parts ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Phytochemical, pharmacological, pharmacokinetic and toxicological characteristics ofFrontiers in pharmacology · 2024Review
- Integrating Network Pharmacology and Component Analysis to Study the Potential Mechanisms of Qi-Fu-Yin Decoction in Treating Alzheimer's Disease.Drug design, development and therapy · 2023Article
- Optimization of ultrasound-assisted extraction method for phytochemical compounds and antioxidant activities of sour jujube extracts.Food science & nutrition · 2022Article
- Comprehensive Quality Evaluation for Medicinal and Edible Ziziphi Spinosae Semen before and after Rancidity Based on Traditional Sensory, Physicochemical Characteristics, and Volatile Compounds.Foods (Basel, Switzerland) · 2022Article
- Gao-Zi-Yao improves learning and memory function in old spontaneous hypertensive rats.BMC complementary medicine and therapies · 2022Article
- Kihito prevents corticosterone-induced brain dysfunctions in mice.Journal of traditional and complementary medicine · 2021Article
- Jujuboside B Inhibits Neointimal Hyperplasia and Prevents Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and MigrationFrontiers in pharmacology · 2021Article
- Traditional Herbal Medicines Against CNS Disorders from Bangladesh.Natural products and bioprospecting · 2020Review
- Revealing the sedative-hypnotic effect of the extracts of herb pair Semen Ziziphi spinosae and Radix Polygalae and related mechanisms through experiments and metabolomics approach.BMC complementary medicine and therapies · 2020Article
- Botanical and Traditional Uses and Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Characteristics ofEvidence-based complementary and alternative medicine : eCAM · 2020Review
- Bioactive compounds, antioxidant and antimicrobial activities of extracts from different plant parts of two Ziziphus Mill. species.PloS one · 2020Article
- Quality control ofJournal of pharmaceutical analysis · 2019Article
- Analysis of the Fungal Community in Ziziphi Spinosae Semen through High-Throughput Sequencing.Toxins · 2018Article
- Simultaneous Quantification of Six Bioactive Components in Decoction of Ziziphi spinosae Semen Using Ultrahigh Performance Liquid Chromatography Coupled with Triple-Quadrupole Mass Spectrometry.Journal of analytical methods in chemistry · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundZiziphi Spinosae Semen (ZSS), the seed of Ziziphus jujuba var. spinosa (Bunge) Hu ex H. F. Chow., is a traditional herb for insomnia and anxiety in eastern Asia. However, few researches have been concerned with its effect on ameliorating memory and learning performance.
objectiveTo investigate the constituents of ZSS water soluble extract and its ameliorating learning and memory in mice. MATERIALS AND
methodsA new high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed and validated to determine the main constituents in the extract. The effect of ZSS water soluble extract on memory and learning performance was investigated in mice by Y-maze and passive avoidance test.
resultsThe extract could significantly decrease the number of errors (NOE), and increase the transfer latency time (TLT) and electrical stimuli time (EST). In addition, spinosin, jujuboside A (JuA) and jujuboside B (JuB) were simultaneously identified and quantified in the extract. Their contents in the extract were as followed: Spinosin (223.51mg/g), JuA (63.76mg/g) and JuB (26.29mg/g).
conclusionThe extract played a promising role in ameliorating memory in mice with alcohol induced memory retrieval disorders, and might help to improve learning capacity to some extent. Spinosin, JuA and JuB were the predominant constituents, which might be mainly responsible for the definite activity.
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