Evidence map›Paper›PMID 25422529›Full record

ArticleJournal of medical primatology2014

Large scale pedigree analysis leads to evidence for founder effects of Hypertrophic Cardiomyopathy in Rhesus Macaques (

Sree Kanthaswamy, Rachel Reader, Ross Tarara, Karen Oslund, Mark Allen, Jillian Ng, Chloe Grinberg, Dallas Hyde, David Glenn Glenn, Nicholas Lerche

Abstract read
In one paragraph

Article in Journal of medical primatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Pedigree Data from Six Rhesus Macaque (Journal of the American Association for Laboratory Animal Science : JAALAS · 2023
    Article
  9. Review
  10. Article
  11. Comparative medicine · 2020
    Article
  12. Article
  13. Article
  14. Inherited cardiomyopathies in veterinary medicine.Pflugers Archiv : European journal of physiology · 2019
    Review
  15. Article
  16. A One Health Approach to Hypertrophic Cardiomyopathy.The Yale journal of biology and medicine · 2017
    Review
  17. Echocardiographic Parameters of Clinically Normal Geriatric Rhesus Macaques (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sree KanthaswamyDepartment of Anthropology, University of California, Davis, CA 95616 ; California National Primate Research Center, University of California, Davis, CA 95616 ; Department of Environmental Toxicology, University of California, Davis, CA 95616.
Rachel ReaderCalifornia National Primate Research Center, University of California, Davis, CA 95616.
Ross TararaCalifornia National Primate Research Center, University of California, Davis, CA 95616.
Karen OslundCalifornia National Primate Research Center, University of California, Davis, CA 95616.
Mark AllenCalifornia National Primate Research Center, University of California, Davis, CA 95616.
Jillian NgCalifornia National Primate Research Center, University of California, Davis, CA 95616.
Chloe GrinbergCalifornia National Primate Research Center, University of California, Davis, CA 95616.
Dallas HydeCalifornia National Primate Research Center, University of California, Davis, CA 95616 ; School of Veterinary Medicine, University of California, Davis, CA 95616.
David Glenn GlennDepartment of Anthropology, University of California, Davis, CA 95616 ; California National Primate Research Center, University of California, Davis, CA 95616.
Nicholas LercheCalifornia National Primate Research Center, University of California, Davis, CA 95616.

Funding

ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI BARRY, PETER A · 1985 to 2011
$126.2M
PRODUCTION OF PEDIGREED SPF RHESUS MACAQUES: HIV VACCINE DVMTU42RR016023 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI LERCHE, NICHOLAS WILLIAM · 2000 to 2011
$13.0M
GENETIC MANAGEMENT OF MECAQUES BY DNA RFLP ANALYSISR24RR005090 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI SMITH, DAVID GLENN · 1988 to 2011
$3.7M
Animal Model for SIV Infection ControlR01RR025781 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APETREI, CRISTIAN, VASILE PANDREA, IVONA · 2009 to 2010
$1.9M
NCRR NIH HHS P51 RR000169NCRR NIH HHS R01 RR025781NCRR NIH HHS R24 RR005090NCRR NIH HHS U42 RR016023
6 · The paper itself

Abstract

Hypertrophic Cardiomyopathy (HCM) is the abnormal thickening of the ventricles and an increase in cardiac mass. Analyses of 108 rhesus macaque probands with pronounced HCM revealed a strong genetic predisposition to this disease. Macaques are ideal for investigating HCM because of their marked similarity to humans genetically, physiologically and anatomically.

Indexed as

Genetic diseaseheart diseaseleft ventricular hypertrophynonhuman primates

Identifiers

PMID25422529
PMCPMC4240635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.