ArticleJournal of experimental botany2015
Two metal-tolerance proteins, MTP1 and MTP4, are involved in Zn homeostasis and Cd sequestration in cucumber cells.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 75 citations in OpenAlex.
- Genomic characterisation of the metal tolerance protein gene family and elucidation of functional role in heavy metal tolerance and accumulation inFrontiers in plant science · 2025Article
- Molecular characterization and expression patterns of MTP genes under heavy metal stress in mustard (Brassica juncea L.).Scientific reports · 2024Article
- Article
- Identification and evolutionary analysis of the metal-tolerance protein family in eight Cucurbitaceae species.The plant genome · 2022Article
- Physiological and Transcriptomic Comparison of Two Sunflower (Frontiers in plant science · 2022Article
- Comprehensive genome wide identification and expression analysis ofSaudi journal of biological sciences · 2021Article
- Melatonin Confers Plant Cadmium Tolerance: An Update.International journal of molecular sciences · 2021Review
- Medical Plant Extract Purification from Cadmium(II) Using Modified Thermoplastic Starch and Ion Exchangers.Materials (Basel, Switzerland) · 2021Article
- Combined transcriptomic, proteomic and biochemical approaches to identify the cadmium hyper-tolerance mechanism of turnip seedling leaves.Environmental science and pollution research international · 2021Article
- Genome-Wide Identification and Expression Analysis of Metal Tolerance Protein Gene Family inFrontiers in genetics · 2021Article
- Review
- Genome-Wide Identification of Metal Tolerance Protein Genes inInternational journal of molecular sciences · 2020Article
- Reducing Cadmium Accumulation in Plants: Structure-Function Relations and Tissue-Specific Operation of Transporters in the Spotlight.Plants (Basel, Switzerland) · 2020Review
- Effects of Exogenous Organic Acids on Cd Tolerance Mechanism ofFrontiers in plant science · 2020Article
- The Endophytic FungusMicroorganisms · 2019Article
- Site-specific regulation of transcriptional responses to cadmium stress in the hyperaccumulator, Sedum alfredii: based on stem parenchymal and vascular cells.Plant molecular biology · 2019Article
- Genome-Wide Identification, Comprehensive Gene Feature, Evolution, and Expression Analysis of Plant Metal Tolerance Proteins in Tobacco Under Heavy Metal Toxicity.Frontiers in genetics · 2019Article
- Metal tolerance protein MTP6 affects mitochondrial iron and manganese homeostasis in cucumber.Journal of experimental botany · 2019Article
- Comparative transcriptome analysis revealed key factors for differential cadmium transport and retention in roots of two contrasting peanut cultivars.BMC genomics · 2018Article
- Article
Corrections and comments
- Retraction · 2020-01-23Duplication of/in Article · Manipulation of Images ·
- Retracted
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal-tolerance proteins (MTPs) are divalent cation transporters that have been shown to be essential for metal homeostasis and tolerance in model plants and hyperaccumulators. Due to the lack of genomic resources, studies on MTPs in cultivated crops are lacking. Here, we present the first functional characterization of genes encoding cucumber proteins homologous to MTP1 and MTP4 transporters. CsMTP1 expression was ubiquitous in cucumber plants, whereas CsMTP4 mRNA was less abundant and was not detected in the generative parts of the flowers. When expressed in yeast, CsMTP1 and CsMTP4 were able to complement the hypersensitivity of mutant strains to Zn and Cd through the increased sequestration of metals within vacuoles using the transmembrane electrochemical gradient. Both proteins formed oligomers at the vacuolar membranes of yeast and cucumber cells and localized in Arabidopsis protoplasts, consistent with their function in vacuolar Zn and Cd sequestration. Changes in the abundance of CsMTP1 and CsMTP4 transcripts and proteins in response to elevated Zn and Cd, or to Zn deprivation, suggested metal-induced transcriptional, translational, and post-translational modifications of protein activities. The differences in the organ expression and affinity of both proteins to Zn and Cd suggested that CsMTP1 and CsMTP4 may not be functionally redundant in cucumber cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.