ArticleThe Journal of experimental medicine2014
Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
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Article in The Journal of experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.Nature aging · 2024Article
- Tespa1 facilitates hematopoietic and leukemic stem cell maintenance by restricting c-Myc degradation.Leukemia · 2023Article
- KIT as a master regulator of the mast cell lineage.The Journal of allergy and clinical immunology · 2022Review
- Integrative Genomic-Epigenomic Analysis of Clozapine-Treated Patients with Refractory Psychosis.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.Journal of translational medicine · 2020Article
- Raf kinase inhibitor protein negatively regulates FcεRI-mediated mast cell activation and allergic response.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.Nature communications · 2017Article
- Effects of Cymbidium Root Ethanol Extract on Atopic Dermatitis.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Tespa1 is associated with susceptibility but not severity of rheumatoid arthritis in the Zhejiang Han population in China.Clinical rheumatology · 2015Article
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Authors and funding
17 authors at 4 institutions in 3 countries.
Di WangInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China diwang@zju.edu.cn lu_linrong@zju.edu.cn.
Mingzhu ZhengInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yuanjun QiuInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Chuansheng GuoInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Jian JiInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
Lei LeiInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Xue ZhangInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Jingjing LiangInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Jun LouInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Wei HuangInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Bowen DongInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Songquan WuMedical College of Lishui University, Lishui, Zhejiang 323000, China.
Jianli WangInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yuehai KeInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Xuetao CaoInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai 200433, China.
Yi Ting ZhouInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Linrong LuInstitute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China Institute of Immunology, Program in Molecular and Cellular Biology, Department of Pathology and Pathophysiology, and Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China diwang@zju.edu.cn lu_linrong@zju.edu.cn.
Division of Chemistry · USGuangdong Academy of Agricultural Sciences · CNLishui University · CNSecond Military Medical University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antigen-mediated cross-linking of IgE on mast cells triggers a signaling cascade that results in their degranulation and proinflammatory cytokine production, which are key effectors in allergic reactions. We show that the activation of mast cells is negatively regulated by the newly identified adaptor protein Tespa1. Loss of Tespa1 in mouse mast cells led to hyper-responsiveness to stimulation via FcεRI. Mice lacking Tespa1 also displayed increased sensitivity to IgE-mediated allergic responses. The dysregulated signaling in KO mast cells was associated with increased activation of Grb2-PLC-γ1-SLP-76 signaling within the LAT1 (linker for activation of T cells family, member 1) signalosome versus the LAT2 signalosome. Collectively, these findings show that Tespa1 orchestrates mast cell activation by tuning the balance of LAT1 and LAT2 signalosome assembly.
Indexed as
Adaptor Proteins, Signal TransducingAmino Acid Transport System y+Amino Acid Transport System y+LAnaphylaxisAnimalsCell DegranulationCell MovementChemokinesFusion Regulatory Protein 1, Light ChainsHypersensitivityMast CellsMice, Inbred C57BLMice, KnockoutReceptors, IgESignal TransductionAdaptor Proteins, Signal TransducingAmino Acid Transport System y+Amino Acid Transport System y+LChemokinesFcepsilonRIalpha protein, mouseFusion Regulatory Protein 1, Light ChainsReceptors, IgESlc7a7 protein, mouseSLC7A8 protein, mouseTespa1 protein, mouse
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