Evidence map›Paper›PMID 25422476›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2014

Silk-based resorbable electronic devices for remotely controlled therapy and in vivo infection abatement.

Hu Tao, Suk-Won Hwang, Benedetto Marelli, Bo An, Jodie E Moreau, Miaomiao Yang, Mark A Brenckle, Stanley Kim, David L Kaplan, John A Rogers and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Silk protein plastics for sustained and controlled drug release.International journal of pharmaceutics · 2026
    Article
  6. Review
  7. Organic Electrochemical Transistors in Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Environmental and Ecological Monitoring with Biodegradable Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hu TaoDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155;
Suk-Won HwangDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801;
Benedetto MarelliDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155;
Bo AnDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155;
Jodie E MoreauDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155;
Miaomiao YangDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155;
Mark A BrenckleDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155;
Stanley KimDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801;
David L KaplanDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155; Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155;
John A RogersDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and jrogers@uiuc.edu fiorenzo.omenetto@tufts.edu.
Fiorenzo G OmenettoDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155; Department of Physics, Tufts University, Medford, MA 02155 jrogers@uiuc.edu fiorenzo.omenetto@tufts.edu.

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
NIBIB NIH HHS EB002520NIBIB NIH HHS P41 EB002520
6 · The paper itself

Abstract

A paradigm shift for implantable medical devices lies at the confluence between regenerative medicine, where materials remodel and integrate in the biological milieu, and technology, through the use of recently developed material platforms based on biomaterials and bioresorbable technologies such as optics and electronics. The union of materials and technology in this context enables a class of biomedical devices that can be optically or electronically functional and yet harmlessly degrade once their use is complete. We present here a fully degradable, remotely controlled, implantable therapeutic device operating in vivo to counter a Staphylococcus aureus infection that disappears once its function is complete. This class of device provides fully resorbable packaging and electronics that can be turned on remotely, after implantation, to provide the necessary thermal therapy or trigger drug delivery. Such externally controllable, resorbable devices not only obviate the need for secondary surgeries and retrieval, but also have extended utility as therapeutic devices that can be left behind at a surgical or suturing site, following intervention, and can be externally controlled to allow for infection management by either thermal treatment or by remote triggering of drug release when there is retardation of antibiotic diffusion, deep infections are present, or when systemic antibiotic treatment alone is insufficient due to the emergence of antibiotic-resistant strains. After completion of function, the device is safely resorbed into the body, within a programmable period.

Indexed as

Absorbable ImplantsAnimalsAnti-Infective AgentsBacterial InfectionsBiopolymersDrug Delivery SystemsElectronicsEquipment and SuppliesEquipment DesignHumansMiceMice, Inbred BALB CRadio WavesSilkStaphylococcal InfectionsStaphylococcus aureusAnti-Infective AgentsBiopolymersSilkbiomaterialsdrug deliveryresorbable electronicssilktheranostics

Identifiers

PMID25422476
PMCPMC4267401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.