ArticleProceedings of the National Academy of Sciences of the United States of America2014
Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 56 citations in OpenAlex.
- Bifidobacterium longum subsp. infantis CCFM1445 Promotes Bone Growth in Growing Mice Via Modulating Gut Microbiota and Arginine Metabolism Pathway.Probiotics and antimicrobial proteins · 2026Article
- MECP2 Insufficiency Attenuates RUNX2-Dependent Osteoblast Differentiation via miR-126-3p/DKK1-Mediated Canonical Wnt Signaling Inhibition in Rett Syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Loss of intraflagellar transport 140 in osteoblasts cripples bone fracture healing.Fundamental research · 2025Article
- In vivo dynamics of hard tissue-forming cell origins: Insights from Cre/loxP-based cell lineage tracing studies.The Japanese dental science review · 2024Review
- Regulation of stem cell fate by HSPGs: implication in hair follicle cycling.NPJ Regenerative medicine · 2022Review
- Dikkopf-1 promotes matrix mineralization of osteoblasts by regulating CaBMB reports · 2022Article
- circRNA422 enhanced osteogenic differentiation of bone marrow mesenchymal stem cells during early osseointegration through the SP7/LRP5 axis.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Osteoblast-Specific Wnt Secretion Is Required for Skeletal Homeostasis and Loading-Induced Bone Formation in Adult Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in mice.Journal of orthopaedic translation · 2022Article
- The diverse origin of bone-forming osteoblasts.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Review
- Wnt7a promotes the osteogenic differentiation of human mesenchymal stem cells.International journal of molecular medicine · 2021Article
- The Interaction Between Intracellular Energy Metabolism and Signaling Pathways During Osteogenesis.Frontiers in molecular biosciences · 2021Review
- Review
- Bone marrow osteoprogenitors are depleted whereas osteoblasts are expanded independent of the osteogenic vasculature in response to zoledronic acid.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Possible Contribution of Wnt-Responsive Chondroprogenitors to the Postnatal Murine Growth Plate.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Prediction of pivotal pathways and hub genes associated with osteoporosis by Gibbs sampling.Experimental and therapeutic medicine · 2019Article
- Regulation of Osteoblast Metabolism by Wnt Signaling.Endocrinology and metabolism (Seoul, Korea) · 2018Review
- The role of the Wnt/β-catenin signaling pathway in the proliferation of gold nanoparticle-treated human periodontal ligament stem cells.Stem cell research & therapy · 2018Article
- β-Catenin Directs Long-Chain Fatty Acid Catabolism in the Osteoblasts of Male Mice.Endocrinology · 2018Article
- Identification of stiffness-induced signalling mechanisms in cells from patent and fused sutures associated with craniosynostosis.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Wnt signaling is a critical regulator of bone development, but the identity and role of the Wnt-producing cells are still unclear. We addressed these questions through in situ hybridization, lineage tracing, and genetic experiments. First, we surveyed the expression of all 19 Wnt genes and Wnt target gene Axin2 in the neonatal mouse bone by in situ hybridization, and demonstrated--to our knowledge for the first time--that Osterix-expressing cells coexpress Wnt and Axin2. To track the behavior and cell fate of Axin2-expressing osteolineage cells, we performed lineage tracing and showed that they sustain bone formation over the long term. Finally, to examine the role of Wnts produced by Osterix-expressing cells, we inhibited Wnt secretion in vivo, and observed inappropriate differentiation, impaired proliferation, and diminished Wnt signaling response. Therefore, Osterix-expressing cells produce their own Wnts that in turn induce Wnt signaling response, thereby regulating their proliferation and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.