ArticleBMJ case reports2014
Small cell lung cancer and progressive retinopathy.
Article in BMJ case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Cancer-associated retinopathy preceding the diagnosis of a pulmonary carcinoid tumour.BMJ case reports · 2020Article
- Cancer-associated retinopathy in ampullary pancreatic cancer.BMJ case reports · 2019Article
- A coin-like peripheral small cell lung carcinoma associated with acute paraneoplastic axonal Guillain-Barre-like syndrome.Medicine · 2015Article
- Article
- CRMP-5-IgG Antibody: role in the bilateral uveitis with swollen disc.Romanian journal of ophthalmologyArticle
- Case Report of Seronegative Cancer-Associated Retinopathy in a Patient with Small Cell Lung Carcinoma.Case reports in oncologyArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer-associated retinopathy (CAR) is one of the paraneoplastic neurological syndromes and characterised by retinal degeneration. Autoimmunity between cancer cells and retinal proteins is considered a major cause of CAR. The presence of serum autoantibodies to retinal antigens plays an important role in the diagnosis. A 60-year-old man reporting of visual disturbance and paresthaesia of extremities presented to our hospital. CT scan revealed a massive tumour in the left lower lobe of the lung. Small cell lung cancer was diagnosed histologically with bronchoscopy. Ophthalmological examination showed retinopathy but not optic neuritis. Anti-CV2/collapsin response mediator protein (CRMP)-5 and anti-Hu antibodies were detected by further serum examination. It has been reported that anti-CV2/CRMP5 antibodies are present in patients with neoplasms accompanied by retinopathy as well as optic neuritis. This is the first case of CAR with presence of anti-CV2/CRMP5 antibodies without neuritis.
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