ArticleJournal of bacteriology2015
Functional type 1 secretion system involved in Legionella pneumophila virulence.
Article in Journal of bacteriology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Global climate gradients structure soilbioRxiv : the preprint server for biology · 2026Article
- The Passage of Chaperonins to Extracellular Locations inBiomolecules · 2025Article
- InSeq analysis of definedmBio · 2024Article
- Legionella pneumophila cell surface RtxA release by LapD/LapG and its role in virulence.BMC microbiology · 2024Article
- Bacterial secretion systems contribute to rapid tissue decay in button mushroom soft rot disease.mBio · 2023Article
- Protein sociology of ProA, Mip and other secreted virulence factors at theFrontiers in cellular and infection microbiology · 2023Review
- Role ofFrontiers in microbiology · 2023Review
- Concept about the Virulence Factor ofMicroorganisms · 2022Review
- Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages.PLoS pathogens · 2021Article
- Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.Chemical reviews · 2021Review
- Computational prediction of secreted proteins in gram-negative bacteria.Computational and structural biotechnology journal · 2021Review
- Growth by Insertion: The Family of Bacterial DDxP Proteins.International journal of molecular sciences · 2020Article
- Sensing, Signaling, and Secretion: A Review and Analysis of Systems for Regulating Host Interaction inGenes · 2020Review
- Article
- Assessing the impact, genomics and evolution of type II secretion across a large, medically important genus: the Legionella type II secretion paradigm.Microbial genomics · 2019Article
- Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system.Journal of microbiology (Seoul, Korea) · 2019Review
- AttenuatedBioMed research international · 2019Article
- An N-Terminal Retention Module Anchors the Giant Adhesin LapA of Pseudomonas fluorescens at the Cell Surface: a Novel Subfamily of Type I Secretion Systems.Journal of bacteriology · 2018Article
- Crucial Role ofFrontiers in microbiology · 2018Article
- Type II Secretion Substrates ofmBio · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legionella pneumophila is a Gram-negative pathogen found mainly in water, either in a free-living form or within infected protozoans, where it replicates. This bacterium can also infect humans by inhalation of contaminated aerosols, causing a severe form of pneumonia called legionellosis or Legionnaires' disease. The involvement of type II and IV secretion systems in the virulence of L. pneumophila is now well documented. Despite bioinformatic studies showing that a type I secretion system (T1SS) could be present in this pathogen, the functionality of this system based on the LssB, LssD, and TolC proteins has never been established. Here, we report the demonstration of the functionality of the T1SS, as well as its role in the infectious cycle of L. pneumophila. Using deletion mutants and fusion proteins, we demonstrated that the repeats-in-toxin protein RtxA is secreted through an LssB-LssD-TolC-dependent mechanism. Moreover, fluorescence monitoring and confocal microscopy showed that this T1SS is required for entry into the host cell, although it seems dispensable to the intracellular cycle. Together, these results underline the active participation of L. pneumophila, via its T1SS, in its internalization into host cells.
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