ReviewThe Journal of antimicrobial chemotherapy2015
Moving forward with reactive oxygen species involvement in antimicrobial lethality.
Review in The Journal of antimicrobial chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 88 citations in OpenAlex.
- Mitoxantrone synergies with tigecycline againstMicrobiology spectrum · 2026Article
- Bactericidal, Anti-Biofilm, and Stress-Response Modulatory Effects ofFoods (Basel, Switzerland) · 2025Article
- A widely-occurring family of pore-forming effectors broadens the impact of the Serratia Type VI secretion system.The EMBO journal · 2025Article
- Investigation of the effect of dimethyl sulfoxide on growth and biofilm formation ofIranian journal of microbiology · 2025Article
- Increased Expression of Bacterial Cellulose Synthase Genes inBiomacromolecules · 2025Article
- Article
- Synergistic antimicrobial activities of phenolic-rich extract derived from olive pomace and UV-A light against bacterial pathogens and their biofilms.Current research in food science · 2025Article
- The ability in managing reactive oxygen species affectsmSystems · 2024Article
- Ebselen: A Promising Repurposing Drug to Treat Infections Caused by Multidrug-Resistant Microorganisms.Interdisciplinary perspectives on infectious diseases · 2024Review
- Enhancement of β-Lactam-Mediated Killing of Gram-Negative Bacteria by Lysine Hydrochloride.Microbiology spectrum · 2023Article
- Evaluation of the Combined Effect of Artemisinin and Ferroptosis Inducer RSL3 againstInternational journal of molecular sciences · 2022Article
- Omics analyses indicate sdhC/D act as hubs of early response of E. coli to antibiotics.Archives of microbiology · 2022Article
- Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens.Frontiers in cellular and infection microbiology · 2022Review
- Inhibition ofFrontiers in cellular and infection microbiology · 2022Article
- Improved Sample Preparation for Untargeted Metabolomics Profiling of Escherichia coli.Microbiology spectrum · 2021Article
- Inhibitors of bacterial HScience (New York, N.Y.) · 2021Article
- Catalase Protects Biofilm ofAntibiotics (Basel, Switzerland) · 2021Article
- Gain-of-Function Mutations in Acid Stress Response (Antimicrobial agents and chemotherapy · 2021Article
- Oxygen and Metabolism: Digesting Determinants of Antibiotic Susceptibility in the Gut.iScience · 2020Review
- Vitamin K Analogs Influence the Growth and Virulence Potential of Enterohemorrhagic Escherichia coli.Applied and environmental microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Support for the contribution of reactive oxygen species (ROS) to antimicrobial lethality has been refined and strengthened. Killing by diverse antimicrobials is enhanced by defects in genes that protect against ROS, inhibited by compounds that block hydroxyl radical accumulation, and is associated with surges in intracellular ROS. Moreover, support has emerged for a genetic pathway that controls the level of ROS. Since some antimicrobials kill in the absence of ROS, ROS must add to, rather than replace, known killing mechanisms. New work has addressed many of the questions concerning the specificity of dyes used to detect intracellular ROS and the specificity of perturbations that influence ROS surges. However, complexities associated with killing under anaerobic conditions remain to be resolved. Distinctions among primary lesion formation, resistance, direct lesion-mediated killing and a self-destructive stress response are discussed to facilitate efforts to potentiate ROS-mediated bacterial killing and improve antimicrobial efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.