ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2014
Age-related reflex responses from peripheral and central chemoreceptors in healthy men.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Cerebral vasomotor reactivity during hypo- and hypercapnia across the adult lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
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- Impact of aging on cardiovascular dynamics and heart rate variability during passive head-up tilt.Physiological reports · 2025Article
- Pathological and Inflammatory Consequences of Aging.Biomolecules · 2025Review
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- Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies.GeroScience · 2024Review
- Women at Altitude: Sex-Related Physiological Responses to Exercise in Hypoxia.Sports medicine (Auckland, N.Z.) · 2024Review
- Excess ventilation and chemosensitivity in patients with inefficient ventilation and chronic coronary syndrome or heart failure: a case-control study.Frontiers in physiology · 2024Article
- Physiological association of the breakpoint with the duration of hyperventilation.Saudi medical journal · 2023Observational
- Role of Vascular Receptors in the Development of Hypertension in the Elderly Population.The International journal of angiology : official publication of the International College of Angiology, Inc · 2022Article
- Inhibition of peripheral chemoreceptors improves ventilatory efficiency during exercise in heart failure with preserved ejection fraction - a role of tonic activity and acute reflex response.Frontiers in physiology · 2022Article
- Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men.Scientific reports · 2021Article
- Non-REM Apnea and Hypopnea Duration Varies across Population Groups and Physiologic Traits.American journal of respiratory and critical care medicine · 2021Article
- Cerebrovascular Reactivity and Central Arterial Stiffness in Habitually Exercising Healthy Adults.Frontiers in physiology · 2018Article
- Increased body fat is associated with potentiation of blood pressure response to hypoxia in healthy men: relations with insulin and leptin.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study aimed: (i) to characterize reflex responses from peripheral and central chemoreceptors in different age groups of healthy men (<50 years old vs ≥50 years old) and, (ii) to assess, within these groups, whether there is any relationship between ventilatory and hemodynamic responses from chemoreceptors and indices of autonomic nervous system (ANS).
methodsPeripheral chemoreflex sensitivity was assessed by the transient hypoxia method and respiratory, heart rate (HR) and blood pressure responses were calculated. Central chemoreflex sensitivity was assessed by the rebreathing method and respiratory response was calculated. ANS was assessed using heart rate variability indices and baroreflex sensitivity (BRS).
resultsSixty-seven healthy men were divided into 2 groups: <50 years (n = 38, mean age: 32 ± 10 years) and ≥50 years (n = 29, mean age: 61 ± 8 years). There were no differences in respiratory response from central and peripheral chemoreceptors between the older and younger groups of healthy males. We found a significantly different pattern of hemodynamic responses from peripheral chemoreceptors between the older and the younger groups. The former expressed attenuated HR acceleration and exaggerated blood pressure increase in response to transient hypoxia. Blunted HR response was related to reduced BRS and sympathovagal imbalance characterized by reduced vagal tone. Blood pressure responses seemed to be independent of sympathovagal balance and BRS.
interpretationAgeing impacts hemodynamic rather than respiratory response from chemoreceptors. Impaired arterial baroreflex and sympathovagal imbalance related to ageing may contribute to decreased heart rate response, but not to increased blood pressure response from peripheral chemoreceptors.
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