ReviewNeuropsychology review2014
Negative neuroplasticity in chronic traumatic brain injury and implications for neurorehabilitation.
Review in Neuropsychology review, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Cognitive enhancement through music therapy: meta-analytic evidence across clinical population.Frontiers in public health · 2025Pooled it
- The Role of Neuroinflammation in Shaping Neuroplasticity and Recovery Outcomes Following Traumatic Brain Injury: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Brain changes: aerobic exercise for traumatic brain injury rehabilitation.Frontiers in human neuroscience · 2023Pooled it
- A Systematic Review on Serious Games in Attention Rehabilitation and Their Effects.Behavioural neurology · 2022Pooled it
- A randomized clinical trial of plasticity-based cognitive training in mild traumatic brain injury.Brain : a journal of neurology · 2021Trial
- Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury.Neural plasticity · 2021Trial
- Modeling Progressive Brain Volume Losses in Chronic Moderate Severe Traumatic Brain Injury: Extensive, but Attenuating.Annals of clinical and translational neurology · 2026Article
- Sequential release ofMaterials today. Bio · 2026Article
- A comprehensive review on adaptive plasticity and recovery mechanisms post-acquired brain injury.Neuroprotection (Chichester, England) · 2025Review
- Everyday Memory Questionnaire-Revised (EMQ-R): Psychometric Validation of the European Portuguese Version in Non-Clinical Sample.Behavioral sciences (Basel, Switzerland) · 2025Article
- EEG Spectral Power Changes in Patients With Dysexecutive Syndrome Following Cognitive Intervention.Brain and behavior · 2024Article
- Mobile Application Applied for Cognitive Rehabilitation: A Systematic Review.Life (Basel, Switzerland) · 2024Review
- Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential.Molecular psychiatry · 2024Review
- Development of a serious game-based cognitive rehabilitation system for patients with brain injury.BMC psychiatry · 2023Article
- Adolescent traumatic brain injury leads to incremental neural impairment in middle-aged mice: role of persistent oxidative stress and neuroinflammation.Frontiers in neuroscience · 2023Article
- Exploring the interplay between mechanisms of neuroplasticity and cardiovascular health in aging adults: A multiple linear regression analysis study.Autonomic neuroscience : basic & clinical · 2022Article
- The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model.Brain sciences · 2022Article
- Cognitive efficacy and neural mechanisms of music-based neurological rehabilitation for traumatic brain injury.Annals of the New York Academy of Sciences · 2022Review
- Patterns of change in cortical morphometry following traumatic brain injury in adults.Human brain mapping · 2022Article
- Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Based on growing findings of brain volume loss and deleterious white matter alterations during the chronic stages of injury, researchers posit that moderate-severe traumatic brain injury (TBI) may act to "age" the brain by reducing reserve capacity and inducing neurodegeneration. Evidence that these changes correlate with poorer cognitive and functional outcomes corroborates this progressive characterization of chronic TBI. Borrowing from a framework developed to explain cognitive aging (Mahncke et al., Progress in Brain Research, 157, 81-109, 2006a; Mahncke et al., Proceedings of the National Academy of Sciences of the United States of America, 103(33), 12523-12528, 2006b), we suggest here that environmental factors (specifically environmental impoverishment and cognitive disuse) contribute to a downward spiral of negative neuroplastic change that may modulate the brain changes described above. In this context, we review new literature supporting the original aging framework, and its extrapolation to chronic TBI. We conclude that negative neuroplasticity may be one of the mechanisms underlying cognitive and neural decline in chronic TBI, but that there are a number of points of intervention that would permit mitigation of this decline and better long-term clinical outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.