ArticleAlcoholism, clinical and experimental research2014
Genetic influences on alcohol use behaviors have diverging developmental trajectories: a prospective study among male and female twins.
Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic review of gene-by-intervention studies of alcohol and other substance use.Development and psychopathology · 2021Pooled it
- Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood.Scientific reports · 2021Trial
- Patterns, Predictors, and Correlates of Problematic Alcohol Use and Remission From Adolescence to Early Midlife.Alcohol, clinical & experimental research · 2026Article
- Gonadal Sex and Sex-Chromosome Complement Interact to Affect Ethanol Consumption in Adolescent Four Core Genotypes Mice.Brain sciences · 2026Article
- Trajectories of genetic risk across dimensions of alcohol use behaviors.Addiction (Abingdon, England) · 2026Article
- Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment.The American journal of psychiatry · 2026Article
- Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors.medRxiv : the preprint server for health sciences · 2025Article
- Delineating trajectories of alcohol consumption and alcohol problems from adolescence to young adulthood: An integrated assessment of genetic, familial, and psychosocial factors.Alcohol, clinical & experimental research · 2025Article
- Do polygenic indices capture "direct" effects on child externalizing behavior problems? Within-family analyses in two longitudinal birth cohorts.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency.Behavior genetics · 2024Article
- Do polygenic indices capture "direct" effects on child externalizing behavior? Within-family analyses in two longitudinal birth cohorts.medRxiv : the preprint server for health sciences · 2023Article
- Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts.Molecular psychiatry · 2022Article
- Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk.Translational psychiatry · 2022Article
- Shared molecular genetic risk of alcohol dependence and posttraumatic stress disorder (PTSD).Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples.Translational psychiatry · 2020Article
- Insular Risk Processing Predicts Alcohol Use Via Externalizing Pathway in Male Adolescents.Journal of studies on alcohol and drugs · 2019Article
- Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study.Alcoholism, clinical and experimental research · 2019Article
- FinnTwin12 Cohort: An Updated Review.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Review
- Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students.Development and psychopathology · 2018Article
- Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk.Social science & medicine (1982) · 2018Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundBoth alcohol-specific genetic factors and genetic factors related to externalizing behavior influence problematic alcohol use. Little is known, however, about the etiologic role of these 2 components of genetic risk on alcohol-related behaviors across development. Prior studies conducted in a male cohort of twins suggest that externalizing genetic factors are important for predicting heavy alcohol use in adolescence, whereas alcohol-specific genetic factors increase in importance during the transition to adulthood. In this report, we studied twin brothers and sisters and brother-sister twin pairs to examine such developmental trajectories and investigate whether sex and cotwin sex effects modify these genetic influences.
methodsWe used prospective, longitudinal twin data collected between ages 12 and 22 within the population-based FinnTwin12 cohort study (analytic n = 1,864). Our dependent measures of alcohol use behaviors included alcohol initiation (age 12), intoxication frequency (ages 14 and 17), and alcohol dependence criteria (age 22). Each individual's genetic risk of alcohol use disorders (AUD-GR) was indexed by his/her parents' and cotwin's DSM-IV Alcohol Dependence (AD) criterion counts. Likewise, each individual's genetic risk of externalizing disorders (EXT-GR) was indexed with a composite measure of parents' and cotwin's DSM-IV Conduct Disorder and Antisocial Personality Disorder criterion counts.
resultsEXT-GR was most strongly related to alcohol use behaviors during adolescence, while AUD-GR was most strongly related to alcohol problems in young adulthood. Further, sex of the twin and sex of the cotwin significantly moderated the associations between genetic risk and alcohol use behaviors across development: AUD-GR influenced early adolescent alcohol use behaviors in females more than in males, and EXT-GR influenced age 22 AD more in males than in females. In addition, the associations of AUD-GR and EXT-GR with intoxication frequency were greater among 14- and 17-year-old females with twin brothers.
conclusionsWe found divergent developmental trajectories for alcohol-specific and externalizing behavior-related genetic influences on alcohol use behaviors; in early adolescence, genetic influences on alcohol use behaviors are largely nonspecific, and later in adolescence and young adulthood, alcohol-specific genetic influences on alcohol use are more influential. Importantly, within these overall trajectories, several interesting sex differences emerged. We found that the relationship between genetic risk and problematic drinking across development is moderated by the individual's sex and his/her cotwin's sex. AUD-GR influenced adolescent alcohol outcomes in females more than in males and by age 22, EXT-GR influenced AD criteria more for males than females. In addition, the association between genetic risk and intoxication frequency was greater among 14- and 17-year-old females with male cotwins.
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