ArticleThe Journal of veterinary medical science2015
Nutrient starvation affects expression of LC3 family at the feto-maternal interface during murine placentation.
Article in The Journal of veterinary medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Insight of Autophagy in Spontaneous Miscarriage.International journal of biological sciences · 2022Review
- Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells.Frontiers in oncology · 2021Review
- Ruminant Placental Adaptation in Early Maternal Undernutrition: An Overview.Frontiers in veterinary science · 2021Review
- Current Understanding of Autophagy in Pregnancy.International journal of molecular sciences · 2019Review
- The physiological roles of autophagy in the mammalian life cycle.Biological reviews of the Cambridge Philosophical Society · 2019Review
- The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels.Scientific reports · 2019Article
- Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.The EMBO journal · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
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Abstract
LC3 - the mammalian homolog of Atg8 - was found as autophagosome membrane binding protein in mammals and widely used as an autophagosomal marker. LC3A, B and C show different expression patterns in each tissue. The aim of this study was to reveal the differences of expression patterns among LC3 families in mouse placenta under normal condition and nutrient starving condition. LC3A and B were highly expressed in decidual cells. LC3A and B were increased in D14 compared with D12 and D16 in mouse placenta, while LC3C was decreased. Starvation induced increase in LC3B expression specifically. Immunohistochemistry showed different expression patterns among LC3A, B and C. LC3A expression in syncytiotrophoblast was vanished by starvation. The results of real time RT-PCR suggested differences between D12 and D16 in autophagic cascade induced by starvation. Taken together, this study suggests that autophagy could play a role in placental invasion system and that nutrient starvation affects LC3B expression.
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