ArticleThe Journal of veterinary medical science2015
Evaluation of sprayed hypochlorous acid solutions for their virucidal activity against avian influenza virus through in vitro experiments.
Article in The Journal of veterinary medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Clinical Study (RCT) Phase 3 of the Safety and Efficacy of Hypochlorous Acid in the Prophylaxis of Healthcare Personnel at High Risk of Infection by SARS-CoV2 (COVID19) Versus Placebo
Intranasal Lavage With Hypochlorous Acid Safely Reduces the Symptoms in the Ambulatory Patient With COVID-19.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of chlorine-based surface disinfection efficacy to inform recommendations for low-resource outbreak settings.American journal of infection control · 2021Pooled it
- Review
- Synergistic antibacterial effect of hydroxyl radicals generated by the combination of hypochlorous acid and UV irradiation.PloS one · 2025Article
- Low-cost, local production of a safe and effective disinfectant for resource-constrained communities.PLOS global public health · 2024Article
- The HOCl dry fog-is it safe for human cells?PloS one · 2024Article
- Development of optimal indoor air disinfection and ventilation protocols for airborne infectious diseases.PloS one · 2024Article
- Evaluation of chlorine dioxide in liquid state and in gaseous state as virucidal agent against avian influenza virus and infectious bronchitis virus.The Journal of veterinary medical science · 2023Article
- Evaluation of antimicrobial efficacies of chlorine dioxide gas released into the air towards pathogens present on the surfaces of inanimate objects.The Journal of veterinary medical science · 2023Article
- The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory-Zoonotic Avian Influenza andApplied biosafety : journal of the American Biological Safety Association · 2023Review
- Hypochlorous acid inactivates oral pathogens and a SARS-CoV-2-surrogate.BMC oral health · 2023Article
- Antimicrobial Efficiency of Hypochlorous Acid and Its Effect on Some Properties of Alginate Impression Material.International journal of dentistry · 2023Article
- Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation.Frontiers in microbiology · 2023Article
- The Lesson Learned from the COVID-19 Pandemic: Can an Active Chemical Be Effective, Safe, Harmless-for-Humans and Low-Cost at a Time? Evidence on Aerosolized Hypochlorous Acid.International journal of environmental research and public health · 2022Article
- Haloperoxidase-mimicking CeONanoscale · 2022Article
- Hypochlorous acid solution is a potent antiviral agent against SARS-CoV-2.Journal of applied microbiology · 2022Article
- New Countermeasures Against Infections with/after COVID-19: Is Chlorine Dioxide a Useful and Safe Disinfectant?Juntendo Iji zasshi = Juntendo medical journal · 2022Article
- Virucidal efficacy of acidic electrolyzed water (AEW) against African swine fever virus and avian influenza virus.The Journal of veterinary medical science · 2021Article
- Article
- Concerns and strategies for wastewater treatment during COVID-19 pandemic to stop plausible transmission.Resources, conservation, and recycling · 2021Review
- Hypochlorous Acid: A Review.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypochlorous acid (HOCl) solutions were evaluated for their virucidal ability against a low pathogenic avian influenza virus (AIV), H7N1. HOCl solutions containing 50, 100 and 200 ppm chlorine (pH 6) or their sprayed solutions (harvested in dishes placed at 1 or 30 cm distance between the spray nozzle and dish) were mixed with the virus with or without organic materials (5% fetal bovine serum: FBS). Under plain diluent conditions (without FBS), harvested solutions of HOCl after spraying could decrease the AIV titer by more than 1,000 times, to an undetectable level (< 2.5 log10TCID50/ml) within 5 sec, with the exception of the 50 ppm solution harvested after spraying at the distance of 30 cm. Under the dirty conditions (in the presence of 5% FBS), they lost their virucidal activity. When HOCl solutions were sprayed directly on the virus on rayon sheets for 10 sec, the solutions of 100 and 200 ppm could inactivate AIV immediately after spraying, while 50 ppm solution required at least 3 min of contact time. In the indirect spray form, after 10 sec of spraying, the lids of the dishes were opened to expose the virus on rayon sheets to HOCl. In this form, the 200 ppm solution inactivated AIV within 10 min of contact, while 50 and 100 ppm could not inactivate it. These data suggest that HOCl can be used in spray form to inactivate AIV at the farm level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.