ArticleMarine drugs2014
Comparative transcriptome analysis of a toxin-producing dinoflagellate Alexandrium catenella and its non-toxic mutant.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- Review
- Toxin Dynamics among Populations of the Bioluminescent HAB SpeciesMarine drugs · 2024Article
- Review
- Transcriptomic analysis reveals the mechanism underlying salinity-induced morphological changes inFrontiers in microbiology · 2024Article
- Genetic association of toxin production in the dinoflagellateMicrobial genomics · 2022Article
- Cyanotoxin-encoding genes as powerful predictors of cyanotoxin production during harmful cyanobacterial blooms in an inland freshwater lake: Evaluating a novel early-warning system.The Science of the total environment · 2022Article
- Biochemical Mapping ofInternational journal of molecular sciences · 2021Article
- Article
- Finding Species-Specific Extracellular Surface-Facing Proteomes in Toxic Dinoflagellates.Toxins · 2021Article
- Insights intoBiology · 2021Article
- Article
- From theFrontiers in microbiology · 2021Article
- De novo Transcriptome of the Non-saxitoxin ProducingMarine drugs · 2020Article
- Biosynthesis of Saxitoxin in Marine Dinoflagellates: An Omics Perspective.Marine drugs · 2020Review
- Omics Analysis for Dinoflagellates Biology Research.Microorganisms · 2019Review
- The Genetic Basis of Toxin Biosynthesis in Dinoflagellates.Microorganisms · 2019Review
- Transcriptomic Profile and Sexual Reproduction-Relevant Genes ofFrontiers in microbiology · 2019Article
- iTRAQ-Based Quantitative Proteomic Analysis of a Toxigenic DinoflagellateMarine drugs · 2018Article
- iTRAQ-Based Quantitative Proteomic Analysis of a Toxigenic DinoflagellateFrontiers in microbiology · 2018Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dinoflagellates and cyanobacteria are two major kingdoms of life producing paralytic shellfish toxins (PSTs), a large group of neurotoxic alkaloids causing paralytic shellfish poisonings around the world. In contrast to the well elucidated PST biosynthetic genes in cyanobacteria, little is known about the dinoflagellates. This study compared transcriptome profiles of a toxin-producing dinoflagellate, Alexandrium catenella (ACHK-T), and its non-toxic mutant form (ACHK-NT) using RNA-seq. All clean reads were assembled de novo into a total of 113,674 unigenes, and 66,812 unigenes were annotated in the known databases. Out of them, 35 genes were found to express differentially between the two strains. The up-regulated genes in ACHK-NT were involved in photosynthesis, carbon fixation and amino acid metabolism processes, indicating that more carbon and energy were utilized for cell growth. Among the down-regulated genes, expression of a unigene assigned to the long isoform of sxtA, the initiator of toxin biosynthesis in cyanobacteria, was significantly depressed, suggesting that this long transcript of sxtA might be directly involved in toxin biosynthesis and its depression resulted in the loss of the ability to synthesize PSTs in ACHK-NT. In addition, 101 putative homologs of 12 cyanobacterial sxt genes were identified, and the sxtO and sxtZ genes were identified in dinoflagellates for the first time. The findings of this study should shed light on the biosynthesis of PSTs in the dinoflagellates.
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