ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2016
Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- A systematic review of factors associated with the patient and diagnostic intervals in gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Pooled it
- Early Weight Loss as a Prognostic Factor in Patients with Advanced Gastric Cancer: Analyses from REGARD, RAINBOW, and RAINFALL Phase III Studies.The oncologist · 2021Pooled it
- Chemotherapy for advanced gastric cancer.The Cochrane database of systematic reviews · 2017Pooled it
- NCancer communications (London, England) · 2025Article
- Causal Inference Methods Based on Pseudo-Observations: A Comparative Analysis of Treatment Types for Iranian Gastrointestinal Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Development and validation of a nomogram to predict cancer-specific survival of elderly patients with unresected gastric cancer who received chemotherapy.Scientific reports · 2024Article
- Outcomes and Prognostic Factors of Metastatic Gastric Cancer: A Single-Center Experience.Cureus · 2022Article
- Pretreatment serum albumin-to-alkaline phosphatase ratio is an independent prognosticator of survival in patients with metastatic gastric cancer.World journal of gastrointestinal oncology · 2022Article
- Machine Learning-Based Model for the Prognosis of Postoperative Gastric Cancer.Cancer management and research · 2022Article
- A Nomogram for Predicting the Cancer-Specific Survival of Patients with Initially Diagnosed Metastatic Gastric Cancer.Clinical Medicine Insights. Oncology · 2022Article
- Geographic impact on access to care and survival for non-curative esophagogastric cancer: a population-based study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021Article
- Bioinformatic and integrated analysis identifies an lncRNA-miRNA-mRNA interaction mechanism in gastric adenocarcinoma.Genes & genomics · 2021Article
- Review
- Economic impacts of care by high-volume providers for non-curative esophagogastric cancer: a population-based analysis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- Prognostic role of body composition parameters in gastric/gastroesophageal junction cancer patients from the EXPAND trial.Journal of cachexia, sarcopenia and muscle · 2020Article
- Identification of the Roles of Chromobox Family Members in Gastric Cancer: A Study Based on Multiple Datasets.BioMed research international · 2020Article
- Association Between Intermediate-Acting Neuromuscular-Blocking Agents and Short-Term Postoperative Outcomes in Patients with Gastric Cancer.Cancer management and research · 2020Article
- Imaging strategies in the management of gastric cancer: current role and future potential of MRI.The British journal of radiology · 2019Review
- A Spatial Survival Model in Presence of Competing Risks for Iranian Gastrointestinal Cancer PatientsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Radical Gastrectomy After Chemotherapy May Prolong Survival in Stage IV Gastric Cancer: A Korean Multi-institutional Analysis.World journal of surgery · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStage IV gastric cancer is lethal, and little population-based research on prognostic factors has been performed in low-incidence countries. Therefore, we investigated the consistency of the associations of patient, disease and healthcare system factors identified in previous population-based research to understand their generalizability to other low-incidence populations.
methodsA population-based, retrospective cohort study of patients diagnosed with Stage IV gastric cancer in Ontario between 1 April 2005 and 31 March 2008 was performed. Kaplan-Meier methodology and the log-rank test were used for bivariate analysis. Multivariate Cox proportional hazard regression was performed. Hazard ratios (HRs) and 95% confidence intervals (CIs) are presented.
resultsOn multivariate analysis, patient, disease and healthcare system factors were independent predictors of survival. Increasing age per 10 years (HR 1.07; 95% CI 1.02-1.10), a tumor located in the gastroesophageal junction (HR 1.09; 95% CI 0.94-1.27) or middle of the stomach (HR 1.14; 95% CI 0.97-1.35), presence of carcinomatosis (HR 1.61; 95% CI 1.42-1.83) and a larger burden of metastatic disease (2-3 sites of metastatic disease: HR 1.17; 95% CI 1.03-1.32; ≥ 4 sites: HR 1.69; 95% CI 1.30-2.20) were associated with worse prognosis. Female gender, receipt of surgery, chemotherapy and radiotherapy and treatment from a high-volume, gastric cancer specialist were all associated with significantly better prognosis. In addition, there was evidence of significant geographic variation in survival.
conclusionThis study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration.
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