ReviewNature reviews. Cardiology2015
Early detection of pulmonary arterial hypertension.
Review in Nature reviews. Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Predictors, prevalence and prognostic role of pulmonary hypertension in patients with chronic kidney disease: a systematic review and meta-analysis.Renal failure · 2024Pooled it
- A systematic review of genetic mutations in pulmonary arterial hypertension.BMC medical genetics · 2017Pooled it
- The Relationship Between Vortical Flow and Pressure Gradient Reversal in Pulmonary Hypertension-A 4D Analysis of Cardiovascular Magnetic Resonance Flow Imaging.Pulmonary circulation · 2026Article
- Recurrent Seizure-Like Events in a Toddler With BMPR2-Related Pulmonary Arterial Hypertension.Ochsner journal · 2026Article
- Estimation of mean pulmonary artery pressure by cardiovascular magnetic resonance 4D Flow and compressed sensing.European heart journal. Imaging methods and practice · 2025Article
- Pulmonary Hypertension Detection From Heart Sound Analysis.IEEE transactions on bio-medical engineering · 2025Article
- Wearable Hyperspectral Photoplethysmography Allows Continuous Monitoring of Exercise-Induced Hypertension.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Importance of age at diagnosis of pulmonary hypertension in children living at high altitude: Longitudinal follow-up of 86 patients.Pulmonary circulation · 2025Article
- Right ventricular outflow tract fractional shortening: a novel diagnostic parameter for pulmonary hypertension.The international journal of cardiovascular imaging · 2025Observational
- The disproportionate burden of pulmonary arterial hypertension among the elderly: global, regional, and national trends from 1990 to 2021-findings from the 2021 global burden of disease study.Frontiers in cardiovascular medicine · 2025Article
- Pulmonary hypertension post-liver transplant: A case report.World journal of gastrointestinal surgery · 2024Article
- Towards a Better Prognosis in Patients with Systemic Sclerosis-Related Pulmonary Arterial Hypertension: Recent Developments and Perspectives.Journal of clinical medicine · 2024Review
- The latest definition and classification of pulmonary hypertension.International journal of cardiology. Congenital heart disease · 2024Review
- Early detection of pulmonary arterial hypertension through [Pulmonary circulation · 2024Article
- Article
- The Current Role of Cardiopulmonary Exercise Test in the Diagnosis and Management of Pulmonary Hypertension.Journal of clinical medicine · 2023Review
- The cascade screening in heritable forms of pulmonary arterial hypertension.Pulmonary circulation · 2023Article
- Pharmacotherapy for Pulmonary Hypertension in Infants with Bronchopulmonary Dysplasia: Past, Present, and Future.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Perfusion imaging heterogeneity during NO inhalation distinguishes pulmonary arterial hypertension (PAH) from healthy subjects and has potential as an imaging biomarker.Respiratory research · 2022Article
- Association between income and likelihood of right heart catheterization in individuals with pulmonary hypertension: A US claims database analysis.Pulmonary circulation · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary arterial hypertension (PAH) remains an incurable disease associated with an unacceptably high early mortality, despite advances in therapeutic options. The disease is clinically silent until late in its natural history, when most of the distal pulmonary arteries have been obliterated. Early diagnosis of PAH is associated with improved long-term survival, and screening of at-risk populations is, therefore, a rational strategy to improve outcomes in this condition. Doppler echocardiography is the most widely used screening tool in current clinical practice. The role of evidence-based screening strategies has been clarified by research such as the DETECT study in patients with systemic sclerosis. A multimodal approach, using a range of noninvasive tests, improves the performance of screening algorithms. Right heart catheterization is mandatory to confirm a diagnosis of PAH. Uncertainties exist about the definition and prognostic relevance of pulmonary hypertension during exercise, but accumulating evidence suggests that stress testing of the pulmonary circulation can unmask clinically important early disease. Novel tools for the early detection of pulmonary vascular disease are urgently needed, given the substantial limitations of currently available techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.