ArticleParasitology research2015
MiR-278-3p regulates pyrethroid resistance in Culex pipiens pallens.
Article in Parasitology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- microRNA profiles and functions in mosquitoes.PLoS neglected tropical diseases · 2018Pooled it
- microRNA Targeting Cytochrome P450 Is Involved in Chlorfenapyr Tolerance in the Silkworm,Insects · 2025Article
- miRNA Expression Response ofInsects · 2025Article
- Overexpression of CYP6CY1 is Involved in Imidacloprid Resistance in Sitobion miscanthi (Takahashi) (Homoptera: Aphidae).Neotropical entomology · 2025Article
- Review
- Insights into the role of non-coding RNAs in the development of insecticide resistance in insects.Frontiers in genetics · 2024Review
- An Insight Into the microRNA Profile of the Ectoparasitic MiteFrontiers in cellular and infection microbiology · 2022Article
- Trypsin Genes Are Regulated through the miRNA Bantam and Associated with Drug Sensitivity in the Sea LouseNon-coding RNA · 2021Article
- MiR-279-3p regulates deltamethrin resistance through CYP325BB1 in Culex pipiens pallens.Parasites & vectors · 2021Article
- Comprehensive Transcriptome Analyses in Sea Louse Reveal Novel Delousing Drug Responses Through MicroRNA regulation.Marine biotechnology (New York, N.Y.) · 2021Article
- Profiling of MicroRNAs in Midguts ofFrontiers in genetics · 2021Article
- Four MicroRNAs, miR-13b-3p, miR-278-5p, miR-10483-5p, and miR-10485-5p, Mediate Insecticide Tolerance inFrontiers in genetics · 2021Article
- A systemic study of indoxacarb resistance in Spodoptera litura revealed complex expression profiles and regulatory mechanism.Scientific reports · 2019Article
- Analysis of microRNA profile of Anopheles sinensis by deep sequencing and bioinformatic approaches.Parasites & vectors · 2018Article
- Characterization and potential role of microRNA in the Chinese dominant malaria mosquitoCell & bioscience · 2018Article
- Article
- piRNA-3878 targets P450 (CpCYP307B1) to regulate pyrethroid resistance in Culex pipiens pallens.Parasitology research · 2017Article
- piRNA-3312: A Putative Role for Pyrethroid Resistance in Culex pipiens pallens (Diptera: Culicidae).Journal of medical entomology · 2017Article
- Infections of virulent and avirulent viruses differentially influenced the expression of dicer-1, ago-1, and microRNAs in Bombus terrestris.Scientific reports · 2017Article
- Identification of microRNAs and their response to the stress of plant allelochemicals in Aphis gossypii (Hemiptera: Aphididae).BMC molecular biology · 2017Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
MicroRNAs (miRNAs) regulate gene expression and biological processes including embryonic development, innate immunity, and infection in many species. Emerging evidence indicates that miRNAs are involved in drug resistance. However, little is known about the relationship between the miRNAs and insecticide resistance in mosquitos. Here, we reported that conserved miR-278-3p and its target gene are critical for pyrethroid resistance in Culex pipiens pallens. We found that CYP6AG11 is the target of miR-278-3p, through bioinformatic analysis and experimental verification. The expression level of miR-278-3p was lower, whereas the level of CYP6AG11 was higher in deltamethrin-resistant strain, which were detected using quantitative reverse transcription PCR (qRT-PCR). We also found that CYP6AG11 was regulated by miR-278-3p via a specific target site with the 3' untranslated region (UTR) by luciferase reporter assay. In addition, overexpression of CYP6AG11 in the mosquito C6/36 cells showed better proliferation than the cells with empty vector when treated by deltamethrin at different concentrations. Moreover, the overexpression of miR-278-3p through microinjection led to a significant reduction in the survival rate, and the level of CYP6AG11 was simultaneously reduced. These results indicated that miR-278-3p could regulate the pyrethroid resistance through CYP6AG11.
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