ArticleThe Journal of comparative neurology2015
Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer.
Article in The Journal of comparative neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Nonlinear integration of sensory inputs and behavioral state by a single neuron in C. elegans.Current biology : CB · 2025Article
- Olfactory bulb interneurons - The developmental timeline and targeting defined by embryonic neurogenesis.Molecular and cellular neurosciences · 2025Article
- Timing Matters: Lessons From Perinatal Neurogenesis in the Olfactory Bulb.The Journal of comparative neurology · 2025Article
- Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb.PLoS biology · 2024Article
- Cell type-specific and frequency-dependent centrifugal modulation in olfactory bulb output neurons in vivo.Journal of neurophysiology · 2024Article
- Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination.Cell reports · 2023Article
- Frequency-dependent centrifugal modulation of the activity of different classes of mitral and tufted cells in olfactory bulb.Journal of neurophysiology · 2023Article
- Anatomical and Functional Connectivity at the Dendrodendritic Reciprocal Mitral Cell-Granule Cell Synapse: Impact on Recurrent and Lateral Inhibition.Frontiers in neural circuits · 2022Article
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- Olfactory bulb granule cells: specialized to link coactive glomerular columns for percept generation and discrimination of odors.Cell and tissue research · 2021Article
- An Evolutionary Microcircuit Approach to the Neural Basis of High Dimensional Sensory Processing in Olfaction.Frontiers in cellular neuroscience · 2021Article
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- Predicting brain organization with a computational model: 50-year perspective on lateral inhibition and oscillatory gating by dendrodendritic synapses.Journal of neurophysiology · 2020Review
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- Nanowire arrays restore vision in blind mice.Nature communications · 2018Article
- POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- P/Q Type Calcium Channel Cav2.1 Defines a Unique Subset of Glomeruli in the Mouse Olfactory Bulb.Frontiers in cellular neuroscience · 2018Article
- Direct Recording of Dendrodendritic Excitation in the Olfactory Bulb: Divergent Properties of Local and External Glutamatergic Inputs Govern Synaptic Integration in Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Spatial Structure of Synchronized Inhibition in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Odor information relayed by olfactory bulb projection neurons, mitral and tufted cells (M/T), is modulated by pairs of reciprocal dendrodendritic synaptic circuits in the external plexiform layer (EPL). Interneurons, which are accounted for largely by granule cells, receive depolarizing input from M/T dendrites and in turn inhibit current spread in M/T dendrites via hyperpolarizing reciprocal dendrodendritic synapses. Because the location of dendrodendritic synapses may significantly affect the cascade of odor information, we assessed synaptic properties and density within sublaminae of the EPL and along the length of M/T secondary dendrites. In electron micrographs the M/T to granule cell synapse appeared to predominate and was equivalent in both the outer and inner EPL. However, the dendrodendritic synapses from granule cell spines onto M/T dendrites were more prevalent in the outer EPL. In contrast, individual gephyrin-immunoreactive (IR) puncta, a postsynaptic scaffolding protein at inhibitory synapses used here as a proxy for the granule to M/T dendritic synapse was equally distributed throughout the EPL. Of significance to the organization of intrabulbar circuits, gephyrin-IR synapses are not uniformly distributed along M/T secondary dendrites. Synaptic density, expressed as a function of surface area, increases distal to the cell body. Furthermore, the distributions of gephyrin-IR puncta are heterogeneous and appear as clusters along the length of the M/T dendrites. Consistent with computational models, our data suggest that temporal coding in M/T cells is achieved by precisely located inhibitory input and that distance from the soma is compensated for by an increase in synaptic density.
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