ArticlePsychopharmacology2015
Effects of disrupting medial prefrontal cortex GABA transmission on decision-making in a rodent gambling task.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty.eLife · 2025Article
- Enhanced Risky Choice in Male Rats Elicited by the Acute Pharmacological Stressor Yohimbine Involves Prefrontal Dopamine D1 Receptor Activation.The international journal of neuropsychopharmacology · 2024Article
- Temporal Dynamics Underlying Prelimbic Prefrontal Cortical Regulation of Action Selection and Outcome Evaluation during Risk/Reward Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Advances in understanding meso-cortico-limbic-striatal systems mediating risky reward seeking.Journal of neurochemistry · 2021Review
- GABAergic motor neurons bias locomotor decision-making in C. elegans.Nature communications · 2020Article
- Review: brain neurobiology of gambling disorder based on rodent models.Neuropsychiatric disease and treatment · 2019Review
- Contributions of medial prefrontal cortex to decision making involving risk of punishment.Neuropharmacology · 2018Article
- Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Regulation of sustained attention, false alarm responding and implementation of conditional rules by prefrontal GABAPsychopharmacology · 2017Article
- Fractionating choice: A study on reward discrimination, preference, and relative valuation in the rat (Rattus norvegicus).Journal of comparative psychology (Washington, D.C. : 1983) · 2016Article
- Neuronal Nicotinic Receptors Are Crucial for Tuning of E/I Balance in Prelimbic Cortex and for Decision-Making Processes.Frontiers in psychiatry · 2016Article
- Inactivation of the prelimbic or infralimbic cortex impairs decision-making in the rat gambling task.Psychopharmacology · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleDecision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas that are implicated in decision-making. For example, expression of the GABA-synthesizing enzyme GAD67 is reduced in the dorsolateral PFC of people with schizophrenia.
objectivesThe goal of this experiment was to determine whether disrupting cortical GABA transmission impairs decision-making using a rodent gambling task (rGT).
methodsRats were trained on the rGT until they reached stable performance and then were implanted with guide cannulae aimed at the medial PFC. Following recovery, the effects of intra-PFC infusions of the GABAA receptor antagonist bicuculline methiodide (BMI) or the GABA synthesis inhibitor L-allylglycine (LAG) on performance on the rGT were assessed.
resultsIntracortical infusions of BMI (25 ng/μl/side), but not LAG (10 μg/μl/side), altered decision-making. Following BMI infusions, rats made fewer advantageous choices. Follow-up experiments suggested that the change in decision-making was due to a change in the sensitivity to the punishments, rather than a change in the sensitivity to reward magnitudes, associated with each outcome. LAG infusions increased premature responding, a measure of response inhibition, but did not affect decision-making.
conclusionsBlocking GABAA receptors, but not inhibiting cortical GABA synthesis, within the medial PFC affects decision-making in the rGT. These data provide proof-of-concept evidence that disruptions in GABA transmission can contribute to the decision-making deficits in schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.