Evidence map›Paper›PMID 25420535›Full record

ReviewHormones & cancer2015

Modeling anaplastic thyroid carcinoma in the mouse.

Devora Champa, Antonio Di Cristofano

Open access · bronzeAbstract readReview
In one paragraph

Review in Hormones & cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Mouse models of thyroid cancer: A 2015 update.Molecular and cellular endocrinology · 2016
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Devora ChampaDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Room 302, Bronx, NY, 10461, USA.
Antonio Di Cristofano
Albert Einstein College of Medicine · US

Funding

SPORE in Thyroid CancerP50CA172012 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI FAGIN, JAMES A · 2014 to 2018
$10.3M
Molecular analysis and therapeutic targeting of PI3K signaling in thyroid cancerR01CA128943 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DI CRISTOFANO, ANTONIO · 2009 to 2024
$5.8M
PI3K-mediated metabolic alterations in the pre-neoplastic thyroidR01CA167839 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DI CRISTOFANO, ANTONIO · 2013 to 2017
$1.7M
NCI NIH HHS CA128943NCI NIH HHS CA167839NCI NIH HHS CA172012NCI NIH HHS P50 CA172012NCI NIH HHS R01 CA128943NCI NIH HHS R01 CA167839
6 · The paper itself

Abstract

Anaplastic thyroid carcinoma is the least common form of thyroid cancer; however, it accounts for the majority of deaths associated with this family of malignancies. A number of genetically engineered immunocompetent mouse models recapitulating the genetic and histological features of anaplastic thyroid cancer have been very recently generated and represent an invaluable tool to dissect the mechanisms involved in the progression from indolent, well-differentiated tumors to aggressive, undifferentiated carcinomas and to identify novel therapeutic targets. In this review, we focus on the relevant characteristics associated with these models and on what we have learned in terms of anaplastic thyroid cancer biology, genetics, and response to targeted therapy.

Indexed as

Disease Models, AnimalAnaplasiaAnimalsHumansMiceMitogen-Activated Protein KinasesNeoplasm GradingPatched ReceptorsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-retProto-Oncogene Proteins p21(ras)PTEN PhosphohydrolaseReceptors, Cell SurfaceSignal TransductionThyroid NeoplasmsMitogen-Activated Protein KinasesPatched ReceptorsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-retProto-Oncogene Proteins p21(ras)PTEN PhosphohydrolaseReceptors, Cell Surface

Identifiers

PMID25420535
PMCPMC4312228
OpenAlexW2043242207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.