Trial reportBMC psychiatry2014
Daily electronic monitoring of subjective and objective measures of illness activity in bipolar disorder using smartphones--the MONARCA II trial protocol: a randomized controlled single-blind parallel-group trial.
Trial report in BMC psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02221336 (Daily Electronic Monitoring of Subjective and Objective Measures of Illness Activity in Bipolar Disorder - The MONARCA II Trial), which is not on this map. Cited by 42 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Daily Electronic Monitoring of Subjective and Objective Measures of Illness Activity in Bipolar Disorder - The MONARCA II Trial (MONitoring, treAtment and pRediCtion of bipolAr Disorder Episodes II)
Who cites it
42 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Exploring the Personal Recovery Construct in Bipolar Disorders: Definition, Usage and Measurement. A Systematic Review.Frontiers in psychiatry · 2022Pooled it
- Digital Phenotyping in Bipolar Disorder: Which Integration with Clinical Endophenotypes and Biomarkers?International journal of molecular sciences · 2020Pooled it
- Methodological Challenges in Randomized Controlled Trials on Smartphone-Based Treatment in Psychiatry: Systematic Review.Journal of medical Internet research · 2019Pooled it
- Smartphone-Based Monitoring of Objective and Subjective Data in Affective Disorders: Where Are We and Where Are We Going? Systematic Review.Journal of medical Internet research · 2017Pooled it
- Electronic self-monitoring of mood using IT platforms in adult patients with bipolar disorder: A systematic review of the validity and evidence.BMC psychiatry · 2016Pooled it
- Simple Mobile technology health management tool for people with severe mental illness: a randomised controlled feasibility trial.BMC psychiatry · 2021Trial
- Forecasting Mood in Bipolar Disorder From Smartphone Self-assessments: Hierarchical Bayesian Approach.JMIR mHealth and uHealth · 2020Trial
- Validity and characteristics of patient-evaluated adherence to medication via smartphones in patients with bipolar disorder: exploratory reanalyses on pooled data from the MONARCA I and II trials.Evidence-based mental health · 2020Trial
- Online psycho-education to the treatment of bipolar disorder: protocol of a randomized controlled trial.BMC psychiatry · 2016Trial
- Feasibility of Behavioral Weight Loss Treatment Enhanced with Peer Support and Mobile Health Technology for Individuals with Serious Mental Illness.The Psychiatric quarterly · 2016Trial
- A Qualitative Study of Client-Clinician Text Exchanges in a Mobile Health Intervention for Individuals With Psychotic Disorders and Substance Use.Journal of dual diagnosis · 2016Trial
- Technology-Enhanced Health Care in Smart Homes: Scoping Review of Sensor Technologies, Clinical Applications, Integration Challenges, and Future Directions.JMIR medical informatics · 2026Article
- Digital Phenotyping for Adolescent Mental Health: Feasibility Study Using Machine Learning to Predict Mental Health Risk From Active and Passive Smartphone Data.Journal of medical Internet research · 2026Article
- Day-to-day variability in sleep and activity predict the onset of a hypomanic episode in patients with bipolar disorder.Journal of affective disorders · 2025Observational
- Mindcraft, a Mobile Mental Health Monitoring Platform for Children and Young People: Development and Acceptability Pilot Study.JMIR formative research · 2023Article
- How to make online mood-monitoring in bipolar patients a success? A qualitative exploration of requirements.International journal of bipolar disorders · 2021Article
- Associations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study.International journal of bipolar disorders · 2021Article
- Wearable, Environmental, and Smartphone-Based Passive Sensing for Mental Health Monitoring.Frontiers in digital health · 2021Review
- The Proposition for Bipolar Depression Forecasting Based on Wearable Data Collection.Frontiers in physiology · 2021Review
- An Iterative and Collaborative End-to-End Methodology Applied to Digital Mental Health.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with bipolar disorder often show decreased adherence with mood stabilizers and frequently interventions on prodromal depressive and manic symptoms are delayed. Recently, the MONARCA I randomized controlled trial investigated the effect of electronic self-monitoring using smartphones on depressive and manic symptoms. The findings suggested that patients using the MONARCA system had more sustained depressive symptoms than patients using a smartphone for normal communicative purposes, but had fewer manic symptoms during the trial. It is likely that the ability of these self-monitored measures to detect prodromal symptoms of depression and mania may be insufficient compared to automatically generated objective data on measures of illness activity such as phone usage, social activity, physical activity, and mobility. The Monsenso system, for smartphones integrating subjective and objective measures of illness activity was developed and will be tested in the present trial.
methodsThe MONARCA II trial uses a randomized controlled single-blind parallel-group design. Patients with bipolar disorder according to ICD-10 who previously have been treated at the Copenhagen Clinic for Affective Disorder, Denmark are included and randomized to either daily use of the Monsenso system including an feedback loop between patients and clinicians (the intervention group) or to the use of a smartphone for normal communicative purposes (the control group) for a 9-month trial period. The trial was started in September 2014 and recruitment is ongoing. The outcomes are: differences in depressive and manic symptoms; rate of depressive and manic episodes (primary); automatically generated objective data on measures of illness activity; number of days hospitalized; psychosocial functioning (secondary); perceived stress; quality of life; self-rated depressive symptoms; self-rated manic symptoms; recovery; empowerment and adherence to medication (tertiary) between the intervention group and the control group during the trial. Ethical permission has been obtained. Positive, neutral and negative findings will be published. DISCUSSION: If the system is effective in reducing depressive and/or manic symptoms (and other symptoms of bipolar disorder) and the rate of episodes, there will be basis for extending the use to the treatment of bipolar disorder in general and in larger scale.
trial registrationClinicalTrials.gov NCT02221336. Registered 26th of September 2014.
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