ReviewPsychological bulletin2015
Cardiac autonomic regulation in autism and Fragile X syndrome: a review.
Review in Psychological bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05340608 (Development and Validation of a System for the Anticipation of Challenging Behaviors of People With Autism Spectrum Disorder Based on a Smart Shirt), which is not on this map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development and Validation of a System for the Anticipation of Challenging Behaviors of People With Autism Spectrum Disorder Based on a Smart Shirt: a Mixed-method Design
Who cites it
52 citing papers in PubMed.
- Contrasting Relationships Between Anxiety and Intolerance of Uncertainty in Cornelia de Lange and Fragile X Syndromes.Journal of intellectual disability research : JIDR · 2025Article
- Heart rate defined sustained attention relates to visual attention in autism and fragile X syndrome.Scientific reports · 2025Article
- Heart abnormality associates with a wide spectrum of psychiatric disorders: Evidence from Mendelian randomization analyses.World journal of psychiatry · 2024Article
- Sensory Symptoms and Signs of Hyperarousal in Individuals with Fragile X Syndrome: Findings from the FORWARD Registry and Database Multisite Study.Journal of autism and developmental disorders · 2024Article
- Developmental associations between motor and communication outcomes in Fragile X syndrome: Variation in the context of co-occurring autism.Autism : the international journal of research and practice · 2024Article
- Examining the feasibility and utility of heart rate variability on intervention outcomes targeting emotion regulation in autism: a brief report.Scientific reports · 2024Article
- Resting Heart Rate Variability and Emotion Dysregulation in Adolescents with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2024Article
- Wearable Biosensing to Predict Imminent Aggressive Behavior in Psychiatric Inpatient Youths With Autism.JAMA network open · 2023Article
- An Initial Development and Evaluation of a Culturally Responsive Police Interactions Training for Black Adolescents with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2023Article
- Negative affect and respiratory sinus arrhythmia are differentially related to social anxiety and autism features in autistic preschoolers contrasted to fragile X syndrome.Frontiers in psychiatry · 2023Article
- Higher scores on autonomic symptom scales in pediatric patients with neurodevelopmental disorders of known genetic etiology.Brain and behavior · 2022Article
- Observable Symptoms of Anxiety in Individuals with Fragile X Syndrome: Parent and Caregiver Perspectives.Genes · 2022Article
- Empathy and Anxiety in Young Girls with Fragile X Syndrome.Journal of autism and developmental disorders · 2022Article
- Cluttering in the Speech of Young Men With Fragile X Syndrome.Journal of speech, language, and hearing research : JSLHR · 2022Article
- What is the Effect of Stimulus Complexity on Attention to Repeating and Changing Information in Autism?Journal of autism and developmental disorders · 2022Article
- Slower Peak Pupillary Response to Emotional Faces in Parents of Autistic Individuals.Frontiers in psychology · 2022Article
- Daily Living Skills in Adolescent and Young Adult Males With Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2022Article
- Development and validation of a system for the prediction of challenging behaviors of people with autism spectrum disorder based on a smart wearable shirt: A mixed-methods design.Frontiers in behavioral neuroscience · 2022Article
- Profiles of Autonomic Activity in Autism Spectrum Disorder with and without Anxiety.Journal of autism and developmental disorders · 2021Article
- The effect of ambient sounds on decision-making and heart rate variability in autism.Autism : the international journal of research and practice · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Despite the significance of efforts to understand the biological basis of autism, progress in this area has been hindered, in part, by the considerable heterogeneity in the disorder. Fragile X syndrome (FXS), a monogenic condition associated with high risk for autism, may pave the way for the dissection of biological heterogeneity within idiopathic autism. This article adopts a cross-syndrome biomarker approach to evaluate potentially overlapping profiles of cardiac arousal dysregulation (and broader autonomic dysfunction) in autism and FXS. Approaches such as this, aimed at delineating shared mechanisms across genetic syndromes, hold great potential for improving diagnostic precision, promoting earlier identification, and uncovering key systems that can be targeted in pharmaceutical/behavioral interventions. Biomarker approaches may be vital to deconstructing complex psychiatric disorders and are currently promoted as such by major research initiatives such as the NIMH Research Domain Criteria (RDoC). Evidence reviewed here supports physiological dysregulation in a subset of individuals with autism, as evidenced by patterns of hyperarousal and dampened parasympathetic vagal tone that overlap with the well-documented physiological profile of FXS. Moreover, there is growing support for a link between aberrant cardiac activity and core deficits associated with autism, such as communication and social impairment. The delineation of physiological mechanisms common to autism and FXS could lend insight into relationships between genetic etiology and behavioral endstates, highlighting FMR1 as a potential candidate gene. Research gaps and potential pitfalls are discussed to inform timely, well-controlled biomarker research that will ultimately promote better diagnosis and treatment of autism and associated conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.