Evidence map›Paper›PMID 25420065›Full record

ArticleNature neuroscience2015

Impaired spatial selectivity and intact phase precession in two-dimensional virtual reality.

Zahra M Aghajan, Lavanya Acharya, Jason J Moore, Jesse D Cushman, Cliff Vuong, Mayank R Mehta

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Place cells in CA1 lack topographical organization of firing locations.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  20. AneLife · 2025
    Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Zahra M Aghajan1] W.M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, Los Angeles, California, USA. [2] Department of Physics and Astronomy, University of California at Los Angeles, Los Angeles, California, USA.
Lavanya Acharya1] W.M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, Los Angeles, California, USA. [2] Biomedical Engineering Interdepartmental Program, University of California at Los Angeles, Los Angeles, California, USA.
Jason J Moore1] W.M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, Los Angeles, California, USA. [2] Neuroscience Interdepartmental Program, University of California at Los Angeles, Los Angeles, California, USA.
Jesse D Cushman1] W.M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, Los Angeles, California, USA. [2] Department of Physics and Astronomy, University of California at Los Angeles, Los Angeles, California, USA.
Cliff Vuong1] W.M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, Los Angeles, California, USA. [2] Department of Physics and Astronomy, University of California at Los Angeles, Los Angeles, California, USA.
Mayank R Mehta1] W.M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, Los Angeles, California, USA. [2] Department of Physics and Astronomy, University of California at Los Angeles, Los Angeles, California, USA. [3] Neuroscience Interdepartmental Program, University of California at Los Angeles, Los Angeles, California, USA. [4] Department of Neurology, University of California at Los Angeles, Los Angeles, California, USA. [5] Department of Neurobiology, University of California at Los Angeles, Los Angeles, California, USA.ORCID 0000000320052468

Funding

CRCNS:Presistent Activity in the Entorhinal Cortex in VivoR01MH092925 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MEHTA, MAYANK R · 2010 to 2014
$910k
NIMH NIH HHS 5R01MH092925-02
6 · The paper itself

Abstract

During real-world (RW) exploration, rodent hippocampal activity shows robust spatial selectivity, which is hypothesized to be governed largely by distal visual cues, although other sensory-motor cues also contribute. Indeed, hippocampal spatial selectivity is weak in primate and human studies that use only visual cues. To determine the contribution of distal visual cues only, we measured hippocampal activity from body-fixed rodents exploring a two-dimensional virtual reality (VR). Compared to that in RW, spatial selectivity was markedly reduced during random foraging and goal-directed tasks in VR. Instead we found small but significant selectivity to distance traveled. Despite impaired spatial selectivity in VR, most spikes occurred within ∼2-s-long hippocampal motifs in both RW and VR that had similar structure, including phase precession within motif fields. Selectivity to space and distance traveled were greatly enhanced in VR tasks with stereotypical trajectories. Thus, distal visual cues alone are insufficient to generate a robust hippocampal rate code for space but are sufficient for a temporal code.

Indexed as

Computer GraphicsUser-Computer InterfaceAnimalsElectrophysiological PhenomenaGoalsHippocampusLocomotionMalePhotic StimulationPsychomotor PerformanceRatsRats, Long-EvansSpace Perception

Identifiers

PMID25420065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.