Evidence map›Paper›PMID 25419990›Full record

ArticleThe journal of pain2014

A pain research agenda for the 21st century.

Robert W Gereau, Kathleen A Sluka, William Maixner, Seddon R Savage, Theodore J Price, Beth B Murinson, Mark D Sullivan, Roger B Fillingim

Abstract read
In one paragraph

Article in The journal of pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Medium Increased Risk for Central Sleep Apnea but Not Obstructive Sleep Apnea in Long-Term Opioid Users: A Systematic Review and Meta-Analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016
    Pooled it
  3. A hybrid implementation-effectiveness randomized trial of CYP2D6-guided postoperative pain management.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Trial
  4. Glial cells in neuropathic pain.Physiological reviews · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Gene therapy for chronic pain management.Cell reports. Medicine · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert W GereauThe American Pain Society, Glenview, Illinois; Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri.
Kathleen A SlukaThe American Pain Society, Glenview, Illinois; Department of Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, Iowa.
William MaixnerThe American Pain Society, Glenview, Illinois; Center for Pain Research and Innovation, University of North Carolina, Chapel Hill, North Carolina.
Seddon R SavageThe American Pain Society, Glenview, Illinois; Department of Anesthesiology and Center on Addiction Recovery and Education, Dartmouth Medical School, Hanover, New Hampshire.
Theodore J PriceThe American Pain Society, Glenview, Illinois; School of Brain and Behavioral Sciences, University of Texas at Dallas, Dallas, Texas.
Beth B MurinsonThe American Pain Society, Glenview, Illinois; Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland.
Mark D SullivanThe American Pain Society, Glenview, Illinois; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Roger B FillingimThe American Pain Society, Glenview, Illinois; Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, Florida. Electronic address: Rfilling@ufl.edu.

Funding

Translation Control of Pain PlasticityR01NS065926 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI PRICE, THEODORE J. · 2010 to 2023
$5.7M
AMPK ACTIVATORS FOR THE TREATMENT OF POST-SURGICAL PAINR01GM102575 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI DUSSOR, GREGORY O, PRICE, THEODORE J. · 2013 to 2016
$1.1M
NIGMS NIH HHS R01 GM102575NINDS NIH HHS R01 NS065926
6 · The paper itself

Abstract

unlabelledChronic pain represents an immense clinical problem. With tens of millions of people in the United States alone suffering from the burden of debilitating chronic pain, there is a moral obligation to reduce this burden by improving the understanding of pain and treatment mechanisms, developing new therapies, optimizing and testing existing therapies, and improving access to evidence-based pain care. Here, we present a goal-oriented research agenda describing the American Pain Society's vision for pain research aimed at tackling the most pressing issues in the field. PERSPECTIVE: This article presents the American Pain Society's view of some of the most important research questions that need to be addressed to advance pain science and to improve care of patients with chronic pain.

Indexed as

Chronic PainBiomedical ResearchClinical Trials as TopicEvidence-Based MedicineHealth EducationHealth PolicyHumansSocieties, MedicalUnited StatesChronic painpain educationpain researchpain treatmentresearch funding

Identifiers

PMID25419990
PMCPMC4664454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.