ArticlePloS one2014
Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Systematic Overview of Solid Particles and Their Host Responses.Frontiers in immunology · 2018Pooled it
- Copper overload drives hepatic stellate cell activation via cuproptosis to exacerbate acute liver injury in murine malaria.Parasites & vectors · 2026Article
- Beyond the mouse: organoids, spheroids, and organs-on-chips as the (inevitable) future of malaria research?Malaria journal · 2026Review
- The differential effect of Interferon-gamma on acute kidney injury and parasitemia in experimental malaria.Scientific reports · 2025Article
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- Effects of nanocapsules containing lumefantrine and artemether in an experimental model of cerebral malaria.Discover nano · 2024Article
- Acetylsalicylic acid and dihydroartemisinin combined therapy on experimental malaria-associated acute lung injury: analysis of lung function and the inflammatory process.Malaria journal · 2024Article
- Potential of Enzymatically Synthesized Hemozoin Analog as Th1 Cell Adjuvant.Nanomaterials (Basel, Switzerland) · 2024Article
- Genome-wide liver transcriptomic profiling of a malaria mouse model reveals disturbed immune and metabolic responses.Parasites & vectors · 2023Article
- Plasmodium berghei Purified Hemozoin Associated with DNA Strongly Inhibits P. berghei Liver-Stage Development in BALB/c Mice after Intravenous Inoculation.Infection and immunity · 2023Article
- Hemozoin: a Complex Molecule with Complex Activities.Current clinical microbiology reports · 2021Article
- Differential Effect of Antioxidants Glutathione and Vitamin C on the Hepatic Injuries Induced byBioMed research international · 2021Article
- Protective Effects ofJournal of parasitology research · 2021Article
- Plasmodium infection inhibits tumor angiogenesis through effects on tumor-associated macrophages in a murine implanted hepatoma model.Cell communication and signaling : CCS · 2020Article
- Mesenchymal stromal cells protect against vascular damage and depression-like behavior in mice surviving cerebral malaria.Stem cell research & therapy · 2020Article
- Neutrophil extracellular traps drive inflammatory pathogenesis in malaria.Science immunology · 2019Article
- Mice chronically fed a high-fat diet are resistant to malaria induced by Plasmodium berghei ANKA.Parasitology research · 2019Article
- Malaria infection promotes a selective expression of kinin receptors in murine liver.Malaria journal · 2019Article
- Adrenal hormones mediate disease tolerance in malaria.Nature communications · 2018Article
- Ethanolic extract of the fungus Trichoderma stromaticum decreases inflammation and ameliorates experimental cerebral malaria in C57BL/6 mice.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria is a global disease that clinically affects more than two hundred million people annually. Despite the availability of effective antimalarials, mortality rates associated with severe complications are high. Hepatopathy is frequently observed in patients with severe malarial disease and its pathogenesis is poorly understood. Previously, we observed high amounts of hemozoin or malaria pigment in livers from infected mice. In this study, we investigated whether hemozoin is associated with liver injury in different mouse malaria models. C57BL/6J mice infected with the rodent parasites Plasmodium berghei ANKA, P. berghei NK65 or P. chabaudi AS had elevated serum liver enzymes without severe histological changes in the liver, in line with the observations in most patients. Furthermore, liver enzymes were significantly higher in serum of P. chabaudi AS-infected mice compared to mice infected with the P. berghei parasite strains and a strong positive correlation was found between hepatic hemozoin levels, hepatocyte damage and inflammation in the liver with P. chabaudi AS. The observed liver injury was only marginally influenced by the genetic background of the host, since similar serum liver enzyme levels were measured in infected C57BL/6J and BALB/c mice. Intravenous injection of P. falciparum-derived hemozoin in malaria-free C57BL/6J mice induced inflammatory gene transcription in the liver, suggesting that hemozoin may be involved in the pathogenesis of malaria hepatopathy by inducing inflammation.
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