Evidence map›Paper›PMID 25419961›Full record

ArticleNature methods2015

Acoustic force spectroscopy.

Gerrit Sitters, Douwe Kamsma, Gregor Thalhammer, Monika Ritsch-Marte, Erwin J G Peterman, Gijs J L Wuite

Abstract read
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In one paragraph

Article in Nature methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed.

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  18. Quantitation of DNA Binding Affinity Using Tethered Particle Motion.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  19. Article
  20. Review

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Gerrit Sitters1] Department of Physics and Astronomy, VU University Amsterdam, Amsterdam, the Netherlands. [2] LaserLaB Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands.
Douwe Kamsma1] Department of Physics and Astronomy, VU University Amsterdam, Amsterdam, the Netherlands. [2] LaserLaB Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands.
Gregor ThalhammerDivision for Biomedical Physics, Innsbruck Medical University, Innsbruck, Austria.ORCID 0000000239488045
Monika Ritsch-MarteDivision for Biomedical Physics, Innsbruck Medical University, Innsbruck, Austria.
Erwin J G Peterman1] Department of Physics and Astronomy, VU University Amsterdam, Amsterdam, the Netherlands. [2] LaserLaB Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands.
Gijs J L Wuite1] Department of Physics and Astronomy, VU University Amsterdam, Amsterdam, the Netherlands. [2] LaserLaB Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.

Indexed as

AcousticsAntigen-Antibody ReactionsBiophysical PhenomenaDigoxigeninDNADNA-Binding ProteinsEquipment DesignLab-On-A-Chip DevicesMicrofluidicsMicrospheresMolecular BiologyRec A RecombinasesSpectrum AnalysisDigoxigeninDNADNA-Binding ProteinsRec A Recombinases

Identifiers

PMID25419961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.