Evidence map›Paper›PMID 25419946›Full record

ArticleThe Journal of cardiovascular nursing

Reduced Gray Matter Volume Is Associated With Poorer Instrumental Activities of Daily Living Performance in Heart Failure.

Michael L Alosco, Adam M Brickman, Mary Beth Spitznagel, Atul Narkhede, Erica Y Griffith, Ronald Cohen, Lawrence H Sweet, Richard Josephson, Joel Hughes, John Gunstad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cardiovascular nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
  7. Management of Cognitive Impairment in Heart Failure.Current treatment options in cardiovascular medicine · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Michael L AloscoMichael L. Alosco, MA Graduate student, Department of Psychological Sciences, Kent State University, Ohio. Adam M. Brickman, PhD College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and Associate Professor of Neuropsychology, the Aging Brain, Department of Neurology, Columbia University, New York. Mary Beth Spitznagel, PhD Assistant Professor, Department of Psychological Sciences, Kent State University; and Department of Psychiatry, Summa Health System, Akron City Hospital, Ohio. Atul Narkhede, MS College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York. Erica Y. Griffith, BS College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York. Ronald Cohen, PhD Professor and Director, Cognitive Aging and Memory Program Departments of Neurology Psychiatry and the Institute on Aging, Center for Cognitive Aging and Memory, University of Florida, Gainesville. Lawrence H. Sweet, PhD Gary R. Sperduto Professor of Clinical Psychology, Department of Psychology, University of Georgia, Athens. Richard Josephson, MS, MD Medical Director of CICU and CVP Rehabilitation, University Hospitals Case Medical Center Cleveland; Harrington Heart & Vascular Institute; and Professor of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio. Joel Hughes, PhD Assistant Professor, Department of Psychological Sciences, Kent State University; and Department of Psychiatry, Summa Health System, Akron City Hospital, Akron, Ohio. John Gunstad, PhD Assistant Professor, Department of Psychological Sciences, Kent State University, Ohio.
Adam M Brickman
Mary Beth Spitznagel
Atul Narkhede
Erica Y Griffith
Ronald Cohen
Lawrence H Sweet
Richard Josephson
Joel Hughes
John Gunstad
Kent State University · USPulmonary Vascular Research Institute · GBSumma Akron City Hospital · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Cognitive Benefits of Cardiac Rehabilitation in Heart FailureR01HL089311 · NHLBI · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2008 to 2012
$2.6M
Hemodynamic and Cognitive Function in Cardiovascular DiseaseR01HL084178 · NHLBI · BUTLER HOSPITAL (PROVIDENCE, RI) · PI SWEET, LAWRENCE H · 2007 to 2011
$2.4M
White matter hyperintensities in Aging and DementiaR01AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2010 to 2014
$2.0M
Cognitive Effects of Bariatric SurgeryR01DK075119 · NIDDK · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2006 to 2009
$1.5M
Extended Effects of Bariatric Surgery on Cognitive FunctionR56DK075119 · NIDDK · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2010 to 2010
$296k
NCATS NIH HHS UL1 TR001427NHLBI NIH HHS HL089311NHLBI NIH HHS R01 HL084178NHLBI NIH HHS R01 HL089311NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG034189NIDDK NIH HHS DK075119NIDDK NIH HHS R01 DK075119NIDDK NIH HHS R56 DK075119
6 · The paper itself

Abstract

backgroundHeart failure patients require assistance with instrumental activities of daily living in part because of the high rates of cognitive impairment in this population. Structural brain insult (eg, reduced gray matter volume) is theorized to underlie cognitive dysfunction in heart failure, although no study has examined the association among gray matter, cognition, and instrumental activities of daily living in heart failure.

objectivesThe aim of this study was to investigate the associations among gray matter volume, cognitive function, and functional ability in heart failure.

methodsA total of 81 heart failure patients completed a cognitive test battery and the Lawton-Brody self-report questionnaire to assess instrumental activities of daily living. Participants underwent magnetic resonance imaging to quantify total gray matter and subcortical gray matter volume.

resultsImpairments in instrumental activities of daily living were common in this sample of HF patients. Regression analyses controlling for demographic and medical confounders showed that smaller total gray matter volume predicted decreased scores on the instrumental activities of daily living composite, with specific associations noted for medication management and independence in driving. Interaction analyses showed that reduced total gray matter volume interacted with worse attention/executive function and memory to negatively impact instrumental activities of daily living.

conclusionsSmaller gray matter volume is associated with greater impairment in instrumental activities of daily living in persons with heart failure, possibly via cognitive dysfunction. Prospective studies are needed to clarify the utility of clinical correlates of gray matter volume (eg, cognitive dysfunction) in identifying heart failure patients at risk for functional decline and determine whether interventions that target improved brain and cognitive function can preserve functional independence in this high-risk population.

Indexed as

Activities of Daily LivingAgedAged, 80 and overCognition DisordersExecutive FunctionFemaleGray MatterHeart FailureHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsSocioeconomic Factors

Identifiers

PMID25419946
PMCPMC4440850
OpenAlexW2328019998

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.