Evidence map›Paper›PMID 25419943›Full record

Trial reportThe Journal of cardiovascular nursing

Evidence-Based Heart Failure Medications and Cognition.

Lisa C Bratzke, Debra K Moser, Michele M Pelter, Steven M Paul, Thomas S Nesbitt, Lawton S Cooper, Kathleen A Dracup

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of cardiovascular nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Observational
  7. Review
  8. Review
  9. Management of Cognitive Impairment in Heart Failure.Current treatment options in cardiovascular medicine · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 3 countries.

Lisa C BratzkeLisa C. Bratzke, PhD, RN, ANP-BC Assistant Professor, School of Nursing, University of Wisconsin, Madison. Debra K. Moser, PhD, RN, FAAN Professor and Linda C. Gill Chair, College of Nursing, University of Kentucky, Lexington. Michele M. Pelter, PhD, RN Associate Professor, Orvis School of Nursing, University of Nevada, Reno. Steven M. Paul, PhD Principal Statistician, School of Nursing, University of California, San Francisco. Thomas S. Nesbitt, MD, MPH Associate Vice Chancellor for Strategic Technologies and Alliances, School of Medicine, University of California, Davis. Lawton S. Cooper, MD, MPH Medical Officer, Division of Cardiovascular Sciences, National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, Maryland. Kathleen A. Dracup, PhD, RN, FNP, FAAN Professor Emeritus, School of Nursing, University of California, San Francisco.
Debra K Moser
Michele M Pelter
Steven M Paul
Thomas S Nesbitt
Lawton S Cooper
Kathleen A Dracup
University of Nevada, Reno · US

Funding

Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CHAPPELL, RICHARD J · 2009 to 2018
$16.2M
Improving Self Care Behavior/Outcomes in Rural PatientsR01HL083176 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DRACUP, KATHLEEN A · 2006 to 2010
$4.0M
Brain Alterations And Cognitive Impairment in Older Adults with Heart FailureR00NR012773 · NINR · UNIVERSITY OF WISCONSIN-MADISON · PI BRATZKE, LISA C · 2013 to 2015
$650k
NHLBI NIH HHS R01 HL083176NHLBI NIH HHS R01HL83176NIA NIH HHS P50 AG033514NINR NIH HHS R00 NR012773NINR NIH HHS R00NR012773
6 · The paper itself

Abstract

backgroundThe etiology of cognitive impairment in heart failure (HF) is controversial and likely multifactorial. Physicians may hesitate to prescribe evidence-based HF medication because of concerns related to potential negative changes in cognition among a population that is already frequently impaired. We conducted a study to determine if prescription of evidence-based HF medications (specifically, β-blockers, angiotensin-converting enzyme inhibitors, angiotensin-receptor blocking agents, diuretics, and aldosterone inhibitors) was associated with cognition in a large HF sample.

methodsA total of 612 patients completed baseline data collection for the Rural Education to Improve Outcomes in Heart Failure clinical trial, including information about medications. Global cognition was evaluated using the Mini-Cog.

resultsThe sample mean (SD) age was 66 (13) years, 58% were men, and 89% were white. Global cognitive impairment was identified in 206 (34%) of the 612 patients. Prescription of evidence-based HF medications was not related to global cognitive impairment in this sample. This relationship was maintained even after adjusting for potential confounders (eg, age, education, and comorbid burden).

conclusionPrescription of evidence-based HF medications is not related to low scores on a measure of global cognitive function in rural patients with HF.

Indexed as

Adrenergic beta-AntagonistsAgedAngiotensin-Converting Enzyme InhibitorsCognition DisordersDiureticsFemaleHeart FailureHumansMaleMiddle AgedMineralocorticoid Receptor AntagonistsPatient Education as TopicRural Health ServicesSelf CareAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsDiureticsMineralocorticoid Receptor Antagonists

Identifiers

PMID25419943
PMCPMC4440853
OpenAlexW2322014130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.