ArticleNature medicine2014
Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.
2 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Nature medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 108 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Exploratory, Open-Label Study of Vedolizumab (Anti-alpha4beta7 Antibody) in Subjects With HIV Infection Undergoing Analytical Treatment Interruption
NCT03577782 phase1 / phase2unknown statusnot on this mapstarted 2018, after this paper: background citation
Phase II Clinical Trial to Analyze the Safety and Efficacy of Vedolizumab Combined With Antiretroviral Therapy to Achieve Permanent Virological Remission in HIV-infected Subjects Without Previous Antiretroviral Therapy
Who cites it
108 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- The Hitchhiker Guide to CD4Frontiers in immunology · 2021Pooled it
- Vedolizumab and ART in recent HIV-1 infection unveil the role of α4β7 in reservoir size.JCI insight · 2024Trial
- Live attenuated varicella-zoster virus vaccine does not induce HIV target cell activation.The Journal of clinical investigation · 2019Trial
- Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals.Science translational medicine · 2018Trial
- Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor.PloS one · 2015Trial
- Phenotypic analysis of productively SIV-infected cells in blood and lymphoid tissues of rhesus macaques.Cell reports · 2026Article
- Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Integrin α4β7: Pathogenic Roles in Metabolic and Inflammatory Diseases and Translational Therapeutics.Journal of inflammation research · 2026Review
- Methods to characterize the vaginal microbiome in a rhesus macaque model of simian human immunodeficiency virus (SHIV) transmission uncover epithelium-associated enrichment ofCurrent research in microbial sciences · 2026Article
- HIV infection and immunosenescence: challenges and intervention strategies.BMC medicine · 2025Review
- Opioid-induced immunosuppression of brain myeloid cells in SIV-infected rhesus macaques.Research square · 2025Article
- NK cell activation and CD4+ T cell α4β7 expression are associated with susceptibility to HIV-1.The Journal of clinical investigation · 2025Article
- IL-21 and anti-α4β7 dual therapy during ART promotes immunological and microbiome responses in SIV-infected macaques.JCI insight · 2025Article
- Gut microbiome as a potential mediator linking sexual behaviors to immune profiles in HIV-negative men who have sex with men: a multi-omics study.Frontiers in immunology · 2025Article
- Dual role for microbial short-chain fatty acids in modifying SIV disease trajectory following anti-α4β7 antibody administration.Annals of medicine · 2024Article
- Review
- Proteomic Analysis to Identify Prospective Biomarkers of Treatment Outcome After Microvascular Decompression for Trigeminal Neuralgia: A Preliminary Study.The journal of pain · 2024Article
- Differential expression of HIV target cells CCR5 and α4β7 in tissue resident memory CD4 T cells in endocervix during the menstrual cycle of HIV seronegative women.Frontiers in immunology · 2024Article
- The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7.PLoS pathogens · 2023Article
- Broadly neutralizing antibodies targeting HIV: Progress and challenges.Clinical immunology (Orlando, Fla.) · 2023Review
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 7 institutions in 2 countries.
Siddappa N ByrareddyDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Brianne KallamDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
James ArthosLaboratory of Immunoregulation, National Institute of Allergy &Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.
Claudia CicalaLaboratory of Immunoregulation, National Institute of Allergy &Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.
Fatima NawazLaboratory of Immunoregulation, National Institute of Allergy &Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.
Joseph HiattLaboratory of Immunoregulation, National Institute of Allergy &Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.
Ellen N KershDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Janet M McNichollDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Debra HansonDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Keith A ReimannMass Biologics, University of Massachusetts Medical School, Boston, Massachusetts, USA.
Markus BrameierPrimate Genetics Laboratory, German Primate Center, Leibniz-Institute for Primate Research, Göttingen, Germany.
Lutz WalterPrimate Genetics Laboratory, German Primate Center, Leibniz-Institute for Primate Research, Göttingen, Germany.
Kenneth RogersDivision of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Ann E MayneDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Paul DunbarDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Tara VillingerDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Dawn LittleDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Tristram G ParslowDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Philip J SantangeloWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
Francois Villinger1] Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. [2] Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Anthony S FauciLaboratory of Immunoregulation, National Institute of Allergy &Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.
Aftab A AnsariDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Emory University · USCenters for Disease Control and Prevention · USNational Institute of Allergy and Infectious Diseases · USGerman Primate Center · DENational Institutes of Health · USGeorgia Institute of Technology · USUniversity of Massachusetts Chan Medical School · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MNonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1MRole of HIV Envelope Proteins In Viral Replication and HIV PathogenesisZIAAI000887 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CICALA, CLAUDIA · 2009 to 2025
$15.2MInteraction of HIV envelope with cell surface receptorsZIAAI000883 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ARTHOS, JAMES L · 2009 to 2024
$14.0MGut Homing Cells in SIV infectionR01AI098628 · NIAID · EMORY UNIVERSITY · PI ANSARI, AFTAB A. · 2012 to 2016
$7.0MResource for Nonhuman Primate Immune ReagentsR24OD010947 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI VILLINGER, FRANCOIS J · 2012 to 2025
$4.9MDevelopment of a non-invasive whole body contrast agent for virus detectionR21AI095129 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI SANTANGELO, PHILIP J, VILLINGER, FRANCOIS J · 2011 to 2012
$461kIntramural NIH HHSNIAID NIH HHS AI-098628-01NIAID NIH HHS R01 AI098628NIAID NIH HHS R21 AI095129NIAID NIH HHS U24 AI126683NIH HHS OD 51POD1113NIH HHS P51 OD011132NIH HHS R24 OD010947
Abstract
α4β7 integrin-expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key role in HIV and simian immunodeficiency virus (SIV) pathogenesis. We show here that the administration of an anti-α4β7 monoclonal antibody just prior to and during acute infection protects rhesus macaques from transmission following repeated low-dose intravaginal challenges with SIVmac251. In treated animals that became infected, the GALT was significantly protected from infection and CD4(+) T cell numbers were maintained in both the blood and the GALT. Thus, targeting α4β7 reduces mucosal transmission of SIV in macaques.
Indexed as
AnimalsAntibodies, MonoclonalCD4 Lymphocyte CountCD4-Positive T-LymphocytesCervix UteriColonDNA, ViralFemaleIleumIntegrinsIntestinal MucosaJejunumLymphoid TissueMacaca mulattaMucous MembraneSimian Acquired Immunodeficiency SyndromeAntibodies, MonoclonalDNA, Viralintegrin alpha4beta7Integrins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT02788175ClinicalTrials.gov
NCT03577782ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.