Evidence map›Paper›PMID 25419681›Full record

Trial reportJournal of pediatric gastroenterology and nutrition2015

Extending supplementary feeding for children younger than 5 years with moderate acute malnutrition leads to lower relapse rates.

Indi Trehan, Somalee Banerjee, Ellen Murray, Kelsey N Ryan, Chrissie Thakwalakwa, Kenneth M Maleta, Mark J Manary

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of pediatric gastroenterology and nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Indi Trehan*Department of Pediatrics, Washington University, St Louis, MO †Department of Community Health, University of Malawi, Blantyre, Malawi.
Somalee Banerjee
Ellen Murray
Kelsey N Ryan
Chrissie Thakwalakwa
Kenneth M Maleta
Mark J Manary

Funding

Training of the Pediatric Emergency Physician-ScientistT32HD049338 · NICHD · WASHINGTON UNIVERSITY · PI SCHNADOWER, DAVID · 2007 to 2016
$1.3M
NICHD NIH HHS T32 HD049338NICHD NIH HHS T32-HD049338
6 · The paper itself

Abstract

objectivesChildren with moderate acute malnutrition (MAM) have a high rate of relapse and death in the year following recovery. In this pilot study, we evaluate the long-term benefits of an extended course of nutritional therapy for children with MAM.

methodsRural Malawian children 6 to 59 months old with MAM, defined as a weight-for-height z score (WHZ) between -2 and -3, were provided supplementary feeding for a fixed duration of 12 weeks. The children were then studied for 12 months to assess long-term nutritional status, and compared with children initially treated only until they first reached WHZ > -2.

resultsCompared with children treated until they reached WHZ > -2, children treated for 12 weeks were more likely to remain well nourished (71% vs 63%, P = 0.0015) and maintain more normal anthropometric indices during 12 months of follow-up; there was also a trend towards lower rates of severe acute malnutrition (7% vs 10%, P = 0.067) and death (2% vs 4%, P = 0.082). Regression modeling showed that mid-upper arm circumference and WHZ at the end of supplementary feeding were the most important factors in predicting which children remained well nourished (P < 0.001 for each).

conclusionsThe duration of supplementary feeding for children with MAM may not be as important as their anthropometry in terms of remaining well nourished after initial recovery. The presently accepted recovery criteria of WHZ of -2 may be insufficient for ensuring long-term nutritional health; consideration should be given to setting higher recovery criteria.

Indexed as

Infant Nutritional Physiological PhenomenaNutritional StatusAcute DiseaseBody SizeChild, PreschoolFemaleHumansInfantMalawiMaleMalnutritionPilot ProjectsRecurrenceReference ValuesTime Factors

Identifiers

PMID25419681
PMCPMC4380557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.