ReviewAmerican journal of respiratory and critical care medicine2014
Respiratory complications of organophosphorus nerve agent and insecticide poisoning. Implications for respiratory and critical care.
Review in American journal of respiratory and critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 183 citations in OpenAlex.
- Atypical Neurological Spectrum of Pediatric Organophosphate Poisoning.Indian journal of pediatrics · 2026Article
- Development of a double-pharmacophore workflow for screening subtype-selective MMolecular diversity · 2026Article
- Imidazole as a Pendant Reactivation Ligand Increases Efficacy Scope for Reactivation and Resurrection of Organophosphorus-Inhibited/Aged Cholinesterases by Quinone Methide Precursors.ACS chemical neuroscience · 2026Article
- Predictive models assessing the impact of intensive care unit admission on the outcomes of acutely poisoned patients.Toxicology research · 2025Article
- Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman-Induced Status Epilepticus in Male Rats.CNS neuroscience & therapeutics · 2025Article
- Case report: Treatment of severe phorate poisoning.Frontiers in toxicology · 2025Article
- Microbiological Etiology and Detection of Drug-Resistant Bacteria in Pneumonia in Patients with Organophosphate Poisoning in the Intensive Care Unit.Infection and drug resistance · 2025Article
- White phosphorus munitions: pathophysiology, clinical management, and multidisciplinary perspectives on burn injuries and humanitarian challenges.Frontiers in public health · 2025Review
- Situational analysis of pesticide poisoning and perceptions of autoinjector devices in rural communities in Sri Lanka - a study protocol.Global health action · 2024Article
- Albuterol as an adjuvant in acute anticholinesterase pesticide poisoning: a randomized, placebo-controlled clinical trial.Toxicology research · 2024Article
- A-series agent A-234: initial in vitro and in vivo characterization.Archives of toxicology · 2024Article
- Cardiovascular responses of adult male Sprague-Dawley rats following acute organophosphate intoxication and post-exposure treatment with midazolam with or without allopregnanolone.Archives of toxicology · 2024Article
- Navigating the Neurological Abyss: A Comprehensive Review of Organophosphate Poisoning Complications.Cureus · 2024Review
- Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders.Neuropsychiatric disease and treatment · 2024Review
- Organophosphate Poisoning: Review of Prognosis and Management.Advanced biomedical research · 2024Review
- Mechanisms of Organophosphate Toxicity and the Role of Acetylcholinesterase Inhibition.Toxics · 2023Review
- Organophosphorus Poisoning: Acute Respiratory Distress Syndrome (ARDS) and Cardiac Failure as Cause of Death in Hospitalized Patients.International journal of molecular sciences · 2023Review
- Review
- Preparation and characterization of activated carbon from agricultural wastes and their ability to remove chlorpyrifos from water.Toxicology reports · 2023Article
- Transdermal Delivery of 2-PAM as a Tool to Increase the Effectiveness of Traditional Treatment of Organophosphate Poisoning.International journal of molecular sciences · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Organophosphorus (OP) compound poisoning is a major global public health problem. Acute OP insecticide self-poisoning kills over 200,000 people every year, the majority from self-harm in rural Asia. Highly toxic OP nerve agents (e.g., sarin) are a significant current terrorist threat, as shown by attacks in Damascus during 2013. These anticholinesterase compounds are classically considered to cause an acute cholinergic syndrome with decreased consciousness, respiratory failure, and, in the case of insecticides, a delayed intermediate syndrome that requires prolonged ventilation. Acute respiratory failure, by central and peripheral mechanisms, is the primary cause of death in most cases. However, preclinical and clinical research over the last two decades has indicated a more complex picture of respiratory complications after OP insecticide poisoning, including onset of delayed neuromuscular junction dysfunction during the cholinergic syndrome, aspiration causing pneumonia and acute respiratory distress syndrome, and the involvement of solvents in OP toxicity. The treatment of OP poisoning has not changed over the last 50 years. However, a better understanding of the multiple respiratory complications of OP poisoning offers additional therapeutic opportunities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.