Evidence map›Paper›PMID 25419511›Full record

ArticleJournal of vascular surgery. Venous and lymphatic disorders2014

Low-molecular-weight heparin modulates vein wall fibrotic response in a plasminogen activator inhibitor 1-dependent manner.

Andrea T Obi, Jose A Diaz, Nicole L Ballard-Lipka, Karen J Roelofs, Diana M Farris, Daniel A Lawrence, Peter K Henke, Thomas W Wakefield

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular surgery. Venous and lymphatic disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Insights from experimental post-thrombotic syndrome and potential for novel therapies.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Andrea T ObiSection of Vascular Surgery, Department of Surgery, Conrad Jobst Vascular Research Laboratories, Ann Arbor, Mich.
Jose A DiazSection of Vascular Surgery, Department of Surgery, Conrad Jobst Vascular Research Laboratories, Ann Arbor, Mich.
Nicole L Ballard-LipkaSection of Vascular Surgery, Department of Surgery, Conrad Jobst Vascular Research Laboratories, Ann Arbor, Mich.
Karen J RoelofsSection of Vascular Surgery, Department of Surgery, Conrad Jobst Vascular Research Laboratories, Ann Arbor, Mich.
Diana M FarrisSection of Vascular Surgery, Department of Surgery, Conrad Jobst Vascular Research Laboratories, Ann Arbor, Mich.
Daniel A LawrenceDepartment of Medicine, University of Michigan Medical School, Ann Arbor, Mich.
Peter K HenkeSection of Vascular Surgery, Department of Surgery, Conrad Jobst Vascular Research Laboratories, Ann Arbor, Mich.
Thomas W WakefieldSection of Vascular Surgery, Department of Surgery, Conrad Jobst Vascular Research Laboratories, Ann Arbor, Mich.
Pulmonary Vascular Research Institute · GBUniversity of Michigan–Ann Arbor · US

Funding

ZINC GLUCONATE GLYCINE LOZENGES &VITAMIN C EFFECTS ON COMMON COLDM01RR000042 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUBENFIRE, MELVYN · 1985 to 2007
$40.8M
Unraveling the role of tPA in the neurovascular unitR01HL055374 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti, Daniel A Lawrence · 1995 to 2026
$8.6M
Thrombotic/Fibrinolytic Balance in Cardiac Transplant VasculopathyP01HL089407 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAWRENCE, DANIEL A · 2008 to 2012
$7.9M
Vascular Surgery: Research Training in Vascular BiologyT32HL076123 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K, WAKEFIELD, THOMAS WILLIAM · 2004 to 2019
$1.9M
Mechanism of thrombolytic tPA induced intracerebral hemorrhage after strokeR01NS079639 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAWRENCE, DANIEL A · 2012 to 2016
$1.7M
Vein Wall Fibrotic Injury After DVT is SLC-CCR7 DependentR01HL092129 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K · 2009 to 2012
$1.5M
NCRR NIH HHS M01 RR000042NHLBI NIH HHS P01 HL089407NHLBI NIH HHS R01 HL055374NHLBI NIH HHS R01 HL092129NHLBI NIH HHS T32 HL076123NINDS NIH HHS R01 NS079639
6 · The paper itself

Abstract

backgroundTreatment with low-molecular-weight heparin (LMWH) favorably alters the vein wall response to deep venous thrombosis (DVT), although the mechanisms remain unclear. Previous studies have suggested that LMWH alters the levels of circulating plasminogen activator inhibitor 1 (PAI-1), a known mediator of fibrosis, and may improve endogenous fibrinolysis. We hypothesized that LMWH favorably alters the vein wall response by binding of PAI-1 and acceleration of fibrinolysis.

methodsWild-type and PAI-1

resultsWild-type mice treated with LMWH exhibited diminished vein wall fibrosis (0.6 ± 0.6 vs 1.4 ± 0.2;

conclusionsLMWH did not accelerate venous thrombosis resolution but did protect against vein wall fibrosis in a PAI-1-dependent manner in an occlusive DVT model. Lack of PAI-1 correlated with accelerated venous thrombosis resolution but no protection from fibrosis. PAI-1 inhibition as a treatment strategy for DVT is likely to accelerate clearance of the thrombus but may come at the expense of increased vein wall fibrosis. CLINICAL RELEVANCE: The pathophysiologic mechanism of post-thrombotic syndrome is not well understood clinically or experimentally. In this study, we evaluated the effect of the prominent fibrinolytic mechanism, plasminogen activator inhibitor 1 (PAI-1), and low-molecular-weight heparin (LMWH) on vein wall injury after thrombosis. We show here that LMWH is protective from vein wall fibrosis, but this is abrogated in PAI-1-deleted mice. This is also correlated with monocyte vein wall influx. These data support the clinical observation that LMWH may be protective from post-thrombotic vein wall injury in a PAI-1-dependent manner.

Identifiers

PMID25419511
PMCPMC4235166
OpenAlexW2074668545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.